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InterPro: IPR008982 Viral attachment protein

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UniProtKB

Matches:

304 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR008982 Viral_att

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF49835	Viral_att	304
Signatures in BioMart

InterPro Relationships Help

Children

IPR000978 Adenoviral fiber protein, knob

Found in

IPR000931 Adenovirus fibre protein
IPR002592 Viral attachment sigma 1, reoviral

GO Term annotation Help

Process

GO:0007155 cell adhesion
GO:0008037 cell recognition
GO:0019058 viral infectious cycle

InterPro annotation

Entry Details in BioMart

Abstract

The viral attachment protein domain forms part of the fibre proteins in adenoviruses [1], and the sigma 1 protein in reoviruses [2]. Both proteins are trimers that contain fibrous tails and globular heads (reovirus), or knobs (adenovirus), which are structurally very similar. Both domain cores consist of eight anti-parallel beta-sheets, forming either a beta sandwich (fibre knob), or a beta-barrel (sigma 1 head), with a long loop containing an alpha helix. The remaining loops tend to be longer in the fibre knob. Functionally both the fibre knob and the sigma 1 head are involved in binding selectively to cell surface receptors. The reoviruses bind JAM (junction adhesion molecule), while the adenoviruses use the CAR (Coxsackievirus and adenovirus) receptor, with the exception of subgroup B adenoviruses [3].

Structural links Help

PDB - click here

SCOP: b.21.1.1 , b.83.1.1 , b.83.1.2

CATH: 2.10.25.20 , 2.60.90.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR008982

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P03275 Fiber protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008982	Viral attachment protein
IPR000978	Adenoviral fiber protein, knob
IPR000931	Adenovirus fibre protein
IPR009013	Viral attachment protein, fibre shaft
IPR000939	Adenoviral fiber protein, repeat/shaft region
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science 286 1579-83 1999 [PubMed: 10567268] http://dx.doi.org/10.1126/science.286.5444.1579
2.	Chappell JD, Prota AE, Dermody TS, Stehle T. Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J. 21 1-11 2002 [PubMed: 11782420] http://dx.doi.org/10.1093/emboj/21.1.1
3.	Durmort C, Stehlin C, Schoehn G, Mitraki A, Drouet E, Cusack S, Burmeister WP. Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus. Virology 285 302-12 2001 [PubMed: 11437664] http://dx.doi.org/10.1006/viro.2001.0967

Additional Reading Open in usermanual
	Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T. Adenovirus type 11 binding alters the conformation of its receptor CD46. Nat. Struct. Mol. Biol. 14 2007 164-6 [PubMed: 17220899] http://dx.doi.org/10.1038/nsmb1190
	Papanikolopoulou K, Forge V, Goeltz P, Mitraki A. Formation of highly stable chimeric trimers by fusion of an adenovirus fiber shaft fragment with the foldon domain of bacteriophage t4 fibritin. J. Biol. Chem. 279 2004 8991-8 [PubMed: 14699113] http://dx.doi.org/10.1074/jbc.M311791200
	Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S. Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor. J. Biol. Chem. 281 2006 33704-16 [PubMed: 16923808] http://dx.doi.org/10.1074/jbc.M605316200
	Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, Verlinde CL, Shayakhmetov D, Stehle T, Roffler S, Lieber A. Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. J. Virol. 81 2007 12785-92 [PubMed: 17898059] http://dx.doi.org/10.1128/JVI.01732-07
	Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N. Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J. Virol. 78 2004 7727-36 [PubMed: 15220447] http://dx.doi.org/10.1128/JVI.78.14.7727-7736.2004

InterPro 24.0