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InterPro: IPR006717 Adenovirus E1B protein, N-terminal

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69 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR006717 Adeno_E1B_55K_N

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04623	Adeno_E1B_55K_N	69
Signatures in BioMart

GO Term annotation Help

Process

GO:0009605 response to external stimulus

InterPro annotation

Entry Details in BioMart

Abstract

This domain constitutes the N-terminal of E1B 55 kDa (IPR002612). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA into an unregulated repressor of genes with a p53 binding site [1]. This protects the virus against p53 induced host anitviral responses and prevents apoptosis as induced by the adenovirus E1A protein [1]. The role of the N-terminal in the function of E1B is not known.

Database links Help

PANDIT: PF04623

Taxonomic coverage Help

Example proteins Help

P03243 E1B protein, large T-antigen

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006717	Adenovirus E1B protein, N-terminal
IPR011050	Pectin lyase fold/virulence factor
IPR002612	Adenovirus large t-antigen, E1B 55kDa protein

Publications Open in usermanual
1.	Martin ME, Berk AJ. Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription. Mol. Cell. Biol. 19 3403-14 1999 [PubMed: 10207064] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=10207064

InterPro 23.1