InterPro: IPR005608 Adenovirus minor core protein PV

The nucleoprotein core of adenoviruses consists of a double-stranded DNA molecule, with a covalently linked terminal protein at each end, in association with the highly basic protein VII and the mu peptide, and the more loosely associated protein V [1]. Protein V is also associated with the capsid and appears to provide a bridge between these two structures. After infection of the host cell, the capsid proteins become disassociated and the core is rapidly transported, in a process involving the cellular microtubules, to the nucleus where transcription of viral genes is initiated.

This entry represents protein V of adenoviruses. It has been suggested, though not proven, that this protein is involved in transport of the core virus particle to the nucleus through interaction with the cellular p32 protein [2]. p32 is a protein that is postulated, though again not proven, to be part of a rapid transport system between mitochondria and the nucleus. Protein V is not essential for viral reproduction, but its deletion leads to reduced thermostability and infectivity suggesting that it may play some role in viral assembly [3].