InterPro: IPR005376 Early E2A, DNA/zinc binding

The adenovirus early E2A DNA-binding protein (Ad DBP) is a multifunctional protein required, amongst other things, for DNA replication and transcription control. It binds to single- and double-stranded DNA, as well as to RNA, in a sequence-independent manner. This signature represents the zinc binding domain of the viral DNA- binding protein, which is active in DNA replication. The zinc atoms appear to be required for the stability of the protein fold rather than being involved in direct contacts with the DNA, the protein contains two zinc atoms in different, novel coordinations. Two copies of this domain are found at the C terminus of many members of the family [1].