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InterPro: IPR004868 DNA-directed DNA polymerase, family B, mitochondria/virus

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UniProtKB

Matches:

773 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR004868 DNA-dir_DNA_pol_B_mt/vir

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03175	DNA_pol_B_2	773
Signatures in BioMart

InterPro Relationships Help

Found in

IPR006172 DNA-directed DNA polymerase, family B
IPR014416 DNA-directed DNA polymerase, family B, phi29-like virus
IPR015833 DNA-directed DNA polymerase, family B, mitochondrial linear plasmid

GO Term annotation Help

Process

GO:0006260 DNA replication

Function

GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity

InterPro annotation

Entry Details in BioMart

Abstract

This entry is found in DNA polymerase type B proteins. Proteins in this entry are found in plant and fungal mitochondria, and in viruses.

Structural links Help

PDB - click here

SCOP: c.55.3.5 , e.8.1.1

CATH: 1.10.287.690 , 3.30.1770.10 , 3.30.420.10 , 3.90.1600.10 , 4.10.80.20

Database links Help

Enzyme: EC:2.7.7.7

PANDIT: PF03175

Pfam Clan: CL0194.6

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR004868

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P03680 DNA polymerase

P05468 DNA polymerase

P10582 DNA polymerase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014416	DNA-directed DNA polymerase, family B, phi29-like virus
IPR015833	DNA-directed DNA polymerase, family B, mitochondrial linear plasmid
IPR017966	DNA-directed DNA polymerase, family B, conserved region2
IPR004868	DNA-directed DNA polymerase, family B, mitochondria/virus
IPR017964	DNA-directed DNA polymerase, family B, conserved site
IPR006172	DNA-directed DNA polymerase, family B
IPR012337	Polynucleotidyl transferase, ribonuclease H fold
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Berman AJ, Kamtekar S, Goodman JL, Lazaro JM, de Vega M, Blanco L, Salas M, Steitz TA. Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. EMBO J. 26 2007 3494-505 [PubMed: 17611604] http://dx.doi.org/10.1038/sj.emboj.7601780
	Kamtekar S, Berman AJ, Wang J, Lazaro JM, de Vega M, Blanco L, Salas M, Steitz TA. Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Mol. Cell 16 2004 609-18 [PubMed: 15546620] http://dx.doi.org/10.1016/j.molcel.2004.10.019
	Wang J, Kamtekar S, Berman AJ, Steitz TA. Correction of X-ray intensities from single crystals containing lattice-translocation defects. Acta Crystallogr. D Biol. Crystallogr. 61 2005 67-74 [PubMed: 15608377] http://dx.doi.org/10.1107/S0907444904026721
	Kamtekar S, Berman AJ, Wang J, Lazaro JM, de Vega M, Blanco L, Salas M, Steitz TA. The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J. 25 2006 1335-43 [PubMed: 16511564] http://dx.doi.org/10.1038/sj.emboj.7601027

InterPro 23.1