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InterPro: IPR000978 Adenoviral fiber protein, knob

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Matches:

276 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR000978 Adeno_fiber_knob

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:2.60.90.10	Adeno_fiber_knob	273
Pfam	PF00541	Adeno_knob	276
Signatures in BioMart

InterPro Relationships Help

Parent

IPR008982 Viral attachment protein

Found in

IPR000931 Adenovirus fibre protein

GO Term annotation Help

Process

GO:0007155 cell adhesion
GO:0008037 cell recognition
GO:0019058 viral infectious cycle

InterPro annotation

Entry Details in BioMart

Abstract

Adenoviruses are responsible for diseases such as pneumonia, cystitis, conjunctivitis and diarrhoea, all of which can be fatal to patients who are immunocompromised [1]. Viral infection commences with recognition of host cell receptors by means of specialised proteins on viral surfaces. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fiber protein and is mediated by the globular carboxy-terminal domain of the adenovirus fiber protein, termed the carboxy-terminal knob domain.

Structural links Help

PDB - click here

SCOP: b.21.1.1 , b.83.1.1

CATH: 2.60.90.10

Database links Help

PANDIT: PF00541

Blocks: IPB000978

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR000978

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P03275 Fiber protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008982	Viral attachment protein
IPR000978	Adenoviral fiber protein, knob
IPR000931	Adenovirus fibre protein
IPR009013	Viral attachment protein, fibre shaft
IPR000939	Adenoviral fiber protein, repeat/shaft region
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Xia D, Henry LJ, Gerard RD, Deisenhofer J. Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution. Structure 2 1259-70 1994 [PubMed: 7704534] http://dx.doi.org/10.1016/S0969-2126(94)00126-X

Additional Reading Open in usermanual
	Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T. Adenovirus type 11 binding alters the conformation of its receptor CD46. Nat. Struct. Mol. Biol. 14 2007 164-6 [PubMed: 17220899] http://dx.doi.org/10.1038/nsmb1190
	Papanikolopoulou K, Forge V, Goeltz P, Mitraki A. Formation of highly stable chimeric trimers by fusion of an adenovirus fiber shaft fragment with the foldon domain of bacteriophage t4 fibritin. J. Biol. Chem. 279 2004 8991-8 [PubMed: 14699113] http://dx.doi.org/10.1074/jbc.M311791200
	Seiradake E, Lortat-Jacob H, Billet O, Kremer EJ, Cusack S. Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor. J. Biol. Chem. 281 2006 33704-16 [PubMed: 16923808] http://dx.doi.org/10.1074/jbc.M605316200
	Wang H, Liaw YC, Stone D, Kalyuzhniy O, Amiraslanov I, Tuve S, Verlinde CL, Shayakhmetov D, Stehle T, Roffler S, Lieber A. Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. J. Virol. 81 2007 12785-92 [PubMed: 17898059] http://dx.doi.org/10.1128/JVI.01732-07
	Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N. Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J. Virol. 78 2004 7727-36 [PubMed: 15220447] http://dx.doi.org/10.1128/JVI.78.14.7727-7736.2004

InterPro 24.0