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InterPro: IPR020582 Acetyl-CoA carboxylase, alpha subunit, conserved region

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UniProtKB

Matches:

1419 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR020582 Acetyl_CoA_COase_a_su_cons-reg

Type

Region

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03255	ACCA	1419
Signatures in BioMart

InterPro Relationships Help

Found in

IPR001095 Acetyl-CoA carboxylase, alpha subunit
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal

InterPro annotation

Entry Details in BioMart

Abstract

This entry contains the alpha subunit the acetyl coenzyme A carboxylase complex (EC:6.4.1.2). It catalyses the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [1]. The reaction involves two steps:

Biotin carrier protein + ATP + HCO₃^- -> Carboxybiotin carrier protein + ADP + P_i

Carboxybiotin carrier protein + Acetyl-CoA -> Malonyl-CoA + Biotin carrier protein

Structural links Help

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SCOP: c.14.1.4

Database links Help

Enzyme: EC:6.4.1.2

CluSTr: ALLvsALL:5314:90.9

Pfam Clan: CL0127.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR020582

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2BQ15 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

O19903 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

P0ABD5 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

P74638 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR020582	Acetyl-CoA carboxylase, alpha subunit, conserved region
IPR001095	Acetyl-CoA carboxylase, alpha subunit
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Li SJ, Cronan JE Jr. The genes encoding the two carboxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase. J. Biol. Chem. 267 16841-7 1992 [PubMed: 1355089] http://intl.jbc.org/cgi/content/abstract/267/24/16841

Additional Reading Open in usermanual
	Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, Holley S, Al-Kassim L, Spessard C, Melnick M, Newcomer M, Waldrop GL. The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme. Biochemistry 45 2006 1712-22 [PubMed: 16460018] http://dx.doi.org/10.1021/bi0520479
	Munday MR, Hemingway CJ. The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents. Adv. Enzyme Regul. 39 1999 205-34 [PubMed: 10470374] http://dx.doi.org/10.1016/S0065-2571(98)00016-8

InterPro 23.1