EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR019931 LPXTG-motif cell wall anchor

Protein matches Help

UniProtKB

Matches:

6621 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR019931 LPXTG-motif_cell_wall_anchor

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01167	LPXTG_anchor	6621
Signatures in BioMart

InterPro Relationships Help

Children

IPR001899 Surface protein from Gram-positive cocci

Found in

IPR011838 Pullulanase, extracellular
IPR012969 Fibrinogen binding
IPR014579 Predicted 5'-nucleotidase, SA0022 type
IPR019929 Haem uptake protein IsdB
IPR019930 Haptoglobin-binding haem uptake protein HarA

InterPro annotation

Entry Details in BioMart

Abstract

The LPXTG motif-containing region is found at the C terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Proteins that do not lie at the C terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif.

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR019931

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P02976 Immunoglobulin G-binding protein A

P46530 Neurogenic locus notch homolog protein 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013091	EGF calcium-binding
IPR019931	LPXTG-motif cell wall anchor
IPR000800	Notch domain
IPR006210	EGF-like
IPR008297	Notch
IPR011656	Notch, NODP domain
IPR002482	Peptidoglycan-binding Lysin subgroup
IPR018392	Peptidoglycan-binding lysin domain
IPR003132	Protein A, Ig-binding
IPR013032	EGF-like region, conserved site
IPR002110	Ankyrin repeat
IPR001899	Surface protein from Gram-positive cocci
IPR018097	EGF-like calcium-binding, conserved site
IPR001881	EGF-like calcium-binding
IPR009063	Immunoglobulin/albumin-binding
IPR010660	Notch, NOD domain
IPR020683	Ankyrin repeat-containing domain
IPR005038	Octapeptide repeat
IPR001438	EGF-like, type 2
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000742	EGF-like, type 3
IPR005877	YSIRK Gram-positive signal peptide
IPR003645	Follistatin-like, N-terminal
IPR019948	Gram-positive anchor
IPR006209	EGF
	ModBase
	SWISS-MODEL
	PDB Chain
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Novick RP. Sortase: the surface protein anchoring transpeptidase and the LPXTG motif. Trends Microbiol. 8 2000 148-51 [PubMed: 10754567] http://dx.doi.org/10.1016/S0966-842X(00)01741-8

InterPro 23.1