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InterPro: IPR019830 Malate synthase, conserved site

Protein matches Help

UniProtKB

Matches:

565 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR019830 Malate_synthase_CS

Type

Conserved_site

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS00510	MALATE_SYNTHASE	565
Signatures in BioMart

InterPro Relationships Help

Found in

IPR001465 Malate synthase
IPR006252 Malate synthase A
IPR011076 Malate synthase-like, core

GO Term annotation Help

Process

GO:0006097 glyoxylate cycle

Function

GO:0004474 malate synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

Malate synthase (EC:2.3.3.9) catalyses the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. Malate synthase has a TIM beta/alpha-barrel fold [1].

Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [2]. The signature pattern for this entry is to a very conserved region in the central section of the enzyme.

Database links Help

Enzyme: EC:2.3.3.9

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR019830

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A6ZRW6 Malate synthase 1, glyoxysomal

P08216 Malate synthase, glyoxysomal

P08997 Malate synthase A

P21360 Malate synthase, glyoxysomal

Q10663 Bifunctional glyoxylate cycle protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019830	Malate synthase, conserved site
IPR015813	Pyruvate/Phosphoenolpyruvate kinase, catalytic core
IPR011076	Malate synthase-like, core
IPR018523	Isocitrate lyase/phosphorylmutase, conserved site
IPR006254	Isocitrate lyase
IPR000918	Isocitrate lyase/phosphorylmutase
IPR001465	Malate synthase
IPR006252	Malate synthase A
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Howard BR, Endrizzi JA, Remington SJ. Crystal structure of Escherichia coli malate synthase G complexed with magnesium and glyoxylate at 2.0 A resolution: mechanistic implications. Biochemistry 39 3156-68 2000 [PubMed: 10715138] http://dx.doi.org/10.1021/bi992519h
2.	Bruinenberg PG, Blaauw M, Kazemier B, Ab G. Cloning and sequencing of the malate synthase gene from Hansenula polymorpha. Yeast 6 245-54 1990 [PubMed: 2349836] http://dx.doi.org/10.1002/yea.320060309

InterPro 23.1