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InterPro: IPR019471 Interferon regulatory factor-3

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UniProtKB

Matches:

198 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR019471 Interferon_regulatory_factor-3

Type

Region

Signatures Help

Database	ID	Name	Proteins
Pfam	PF10401	IRF-3	198
Signatures in BioMart

InterPro Relationships Help

Parent

IPR017855 SMAD domain-like

GO Term annotation Help

Process

GO:0006355 regulation of transcription, DNA-dependent

Function

GO:0003700 transcription factor activity

Component

GO:0005634 nucleus

InterPro annotation

Entry Details in BioMart

Abstract

This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha, beta-stimulated gene). IRF-3 pre-exists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.

Structural links Help

PDB - click here

SCOP: b.26.1.3

CATH: 2.60.200.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR019471

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P23611 Interferon regulatory factor 8

Q08DD6 Interferon regulatory factor 6

Q13568 Interferon regulatory factor 5

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019471	Interferon regulatory factor-3
IPR011991	Winged helix repressor DNA-binding
IPR019817	Interferon regulatory factor, conserved site
IPR001346	Interferon regulatory factor
IPR008984	SMAD/FHA domain
IPR017855	SMAD domain-like
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Hiscott J, Lin R. IRF-3 releases its inhibitions. Structure 13 2005 1235-6 [PubMed: 16154077] http://dx.doi.org/10.1016/j.str.2005.08.001
	Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F. X-ray crystal structure of IRF-3 and its functional implications. Nat. Struct. Biol. 10 2003 922-7 [PubMed: 14555995] http://dx.doi.org/10.1038/nsb1001
	Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K. Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat. Struct. Biol. 10 2003 913-21 [PubMed: 14555996] http://dx.doi.org/10.1038/nsb1002
	Weaver BK, Kumar KP, Reich NC. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol. Cell. Biol. 18 1998 1359-68 [PubMed: 9488451]

InterPro 23.1