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InterPro: IPR018371 Chitin-binding, type 1, conserved site

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691 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR018371 Chitin-binding_1_CS

Type

Conserved_site

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS00026	CHIT_BIND_I_1	691
Signatures in BioMart

InterPro Relationships Help

Found in

IPR001002 Chitin-binding, type 1
IPR016283 Glycoside hydrolase, family 19

GO Term annotation Help

Function

GO:0008061 chitin binding

InterPro annotation

Entry Details in BioMart

Abstract

A number of plant and fungal proteins that bind N-acetylglucosamine (e.g. solanaceous lectins of tomato and potato, plant endochitinases, the wound-induced proteins: hevein, win1 and win2, and the Kluyveromyces lactis killer toxin alpha subunit) contain this domain [1]. The domain may occur in one or more copies and is thought to be involved in recognition or binding of chitin subunits [2, 3]. In chitinases, as well as in the potato wound-induced proteins, the 43-residue domain directly follows the signal sequence and is therefore at the N terminus of the mature protein; in the killer toxin alpha subunit it is located in the central section of the protein.

Structural links Help

PDB - click here

SCOP: g.3.1.1 , g.3.1.2

CATH: 3.30.60.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR018371

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P02876 Agglutinin isolectin 2

P09805 Killer toxin subunits alpha/beta

P19171 Basic endochitinase B

Q7DNA1 Chitinase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016283	Glycoside hydrolase, family 19
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR001579	Glycoside hydrolase, chitinase active site
IPR000726	Glycoside hydrolase, family 19, catalytic
IPR001002	Chitin-binding, type 1
IPR002482	Peptidoglycan-binding Lysin subgroup
IPR018392	Peptidoglycan-binding lysin domain
IPR017853	Glycoside hydrolase, catalytic core
IPR018371	Chitin-binding, type 1, conserved site
IPR011583	Chitinase II
IPR001223	Glycoside hydrolase, family 18, catalytic domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Wright HT, Sandrasegaram G, Wright CS. Evolution of a family of N-acetylglucosamine binding proteins containing the disulfide-rich domain of wheat germ agglutinin. J. Mol. Evol. 33 283-94 1991 [PubMed: 1757999] http://dx.doi.org/10.1007/BF02100680
2.	Butler AR, O'Donnell RW, Martin VJ, Gooday GW, Stark MJ. Kluyveromyces lactis toxin has an essential chitinase activity. Eur. J. Biochem. 199 483-8 1991 [PubMed: 2070799] http://dx.doi.org/10.1111/j.1432-1033.1991.tb16147.x
3.	Lerner DR, Raikhel NV. The gene for stinging nettle lectin (Urtica dioica agglutinin) encodes both a lectin and a chitinase. J. Biol. Chem. 267 11085-91 1992 [PubMed: 1375935] http://intl.jbc.org/cgi/reprint/267/16/11085.pdf

Additional Reading Open in usermanual
	Aboitiz N, Vila-Perello M, Groves P, Asensio JL, Andreu D, Canada FJ, Jimenez-Barbero J. NMR and modeling studies of protein-carbohydrate interactions: synthesis, three-dimensional structure, and recognition properties of a minimum hevein domain with binding affinity for chitooligosaccharides. Chembiochem 5 2004 1245-55 [PubMed: 15368576] http://dx.doi.org/10.1002/cbic.200400025
	Fujii T, Hayashida M, Hamasu M, Ishiguro M, Hata Y. Structures of two lectins from the roots of pokeweed (Phytolacca americana). Acta Crystallogr. D Biol. Crystallogr. 60 2004 665-73 [PubMed: 15039554] http://dx.doi.org/10.1107/S090744490400232X
	Wagner S, Breiteneder H. The latex-fruit syndrome. Biochem. Soc. Trans. 30 2002 935-40 [PubMed: 12440950] http://www.biochemsoctrans.org/bst/030/bst0300935.htm
	Reyes-Lopez CA, Hernandez-Santoyo A, Pedraza-Escalona M, Mendoza G, Hernandez-Arana A, Rodriguez-Romero A. Insights into a conformational epitope of Hev b 6.02 (hevein). Biochem. Biophys. Res. Commun. 314 2004 123-30 [PubMed: 14715255] http://dx.doi.org/10.1016/j.bbrc.2003.12.068
	Sowka S, Hsieh LS, Krebitz M, Akasawa A, Martin BM, Starrett D, Peterbauer CK, Scheiner O, Breiteneder H. Identification and cloning of prs a 1, a 32-kDa endochitinase and major allergen of avocado, and its expression in the yeast Pichia pastoris. J. Biol. Chem. 273 1998 28091-7 [PubMed: 9774427] http://dx.doi.org/10.1074/jbc.273.43.28091
	Xiang Y, Huang RH, Liu XZ, Zhang Y, Wang DC. Crystal structure of a novel antifungal protein distinct with five disulfide bridges from Eucommia ulmoides Oliver at an atomic resolution. J. Struct. Biol. 148 2004 86-97 [PubMed: 15363789] http://dx.doi.org/10.1016/j.jsb.2004.04.002
	Asensio JL, Canada FJ, Siebert HC, Laynez J, Poveda A, Nieto PM, Soedjanaamadja UM, Gabius HJ, Jimenez-Barbero J. Structural basis for chitin recognition by defense proteins: GlcNAc residues are bound in a multivalent fashion by extended binding sites in hevein domains. Chem. Biol. 7 2000 529-43 [PubMed: 10903932] http://dx.doi.org/10.1016/S1074-5521(00)00136-8
	Andersen NH, Cao B, Rodriguez-Romero A, Arreguin B. Hevein: NMR assignment and assessment of solution-state folding for the agglutinin-toxin motif. Biochemistry 32 1993 1407-22 [PubMed: 8431421] http://dx.doi.org/10.1021/bi00057a004
	Huang RH, Xiang Y, Tu GZ, Zhang Y, Wang DC. Solution structure of Eucommia antifungal peptide: a novel structural model distinct with a five-disulfide motif. Biochemistry 43 2004 6005-12 [PubMed: 15147184] http://dx.doi.org/10.1021/bi036263y

InterPro 23.1