Prokaryotic ribonuclease PH (EC:2.7.7.56) (RNase PH) is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates [1]. There is a similar protein in Caenorhabditis elegans that belongs to this group.
More information about these proteins can be found at Protein of the Month: RNA Exosomes [2]. This entry represents a highly conserved region which is located in the central part of these proteins.
Harlow LS, Kadziola A, Jensen KF, Larsen S.
Crystal structure of the phosphorolytic exoribonuclease RNase PH from Bacillus subtilis and implications for its quaternary structure and tRNA binding.
Protein Sci. 13 2004 668-77
[PubMed: 14767080] http://dx.doi.org/10.1110/ps.03477004
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