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InterPro: IPR018318 tRNA methyl transferase-like

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UniProtKB

Matches:

3535 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR018318 tRNA_MeTrfase-like

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03054	tRNA_Me_trans	3535
Signatures in BioMart

InterPro Relationships Help

Children

IPR004506 tRNA-specific 2-thiouridylase

Found in

IPR001674 GMP synthase, C-terminal

Contains

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

InterPro annotation

Entry Details in BioMart

Abstract

This entry is found in a number of enzymes, including GMP synthase and the tRNA-specific 2-thiouridylase catalysing the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.

Structural links Help

PDB - click here

SCOP: c.26.2.1

CATH: 2.30.30.280 , 2.40.30.10 , 3.40.50.620

Database links Help

Pfam Clan: CL0039.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR018318

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O75648 Mitochondrial tRNA-specific 2-thiouridylase 1

Q09580 Probable GMP synthase [glutamine-hydrolyzing]

Q12093 Mitochondrial tRNA-specific 2-thiouridylase 1

Q9DAT5 Mitochondrial tRNA-specific 2-thiouridylase 1

Q9W5B6 Mitochondrial tRNA-specific 2-thiouridylase 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011702	Glutamine amidotransferase superfamily
IPR004506	tRNA-specific 2-thiouridylase
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR000991	Glutamine amidotransferase class-I, C-terminal
IPR017926	Glutamine amidotransferase type 1
IPR018318	tRNA methyl transferase-like
IPR004739	GMP synthase, N-terminal
IPR001674	GMP synthase, C-terminal
IPR006220	Anthranilate synthase component II/delta crystallin
	SWISS-MODEL
	ModBase

Publications Help

Additional Reading Open in usermanual
	Tesmer JJ, Klem TJ, Deras ML, Davisson VJ, Smith JL. The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat. Struct. Biol. 3 1996 74-86 [PubMed: 8548458] http://dx.doi.org/10.1038/nsb0196-74
	Hagervall TG, Edmonds CG, McCloskey JA, Bjork GR. Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities. J. Biol. Chem. 262 1987 8488-95 [PubMed: 3298234] http://intl.jbc.org/cgi/content/abstract/262/18/8488
	Numata T, Ikeuchi Y, Fukai S, Suzuki T, Nureki O. Snapshots of tRNA sulphuration via an adenylated intermediate. Nature 442 2006 419-24 [PubMed: 16871210] http://dx.doi.org/10.1038/nature04896

InterPro 23.1