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InterPro: IPR018088 Chalcone/stilbene synthase, active site

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1104 proteins

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Accession

IPR018088 Chalcone/stilbene_synthase_AS

Type

Active_site

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS00441	CHALCONE_SYNTH	1104
Signatures in BioMart

InterPro Relationships Help

Found in

IPR001099 Chalcone/stilbene synthase, N-terminal
IPR011141 Polyketide synthase, type III
IPR016038 Thiolase-like, subgroup
IPR016039 Thiolase-like

GO Term annotation Help

Process

GO:0009058 biosynthetic process

Function

GO:0008415 acyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Synonym(s): Chalcone synthase, Flavonone synthase, 6'-deoxychalcone synthase

Naringenin-chalcone synthases (EC:2.3.1.74) and stilbene synthases (STS) (formerly known as resveratrol synthases) are related plant enzymes. CHS is an important enzyme in flavanoid biosynthesis and STS is a key enzyme in stilbene-type phyloalexin biosynthesis. Both enzymes catalyse the addition of three molecules of malonyl-CoA to a starter CoA ester (a typical example is 4-coumaroyl-CoA), producing either a chalcone (with CHS) or stilbene (with STS) [1].

These enzymes have a conserved cysteine residue, located in the central section of the protein sequence, which is essential for the catalytic activity of both enzymes and probably represents the binding site for the 4-coumaryl-CoA group [2].

Structural links Help

PDB - click here

SCOP: c.95.1.2

CATH: 3.40.47.10

Database links Help

Enzyme: EC:2.3.1.74

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR018088

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A2ZEX7 Chalcone synthase

P13114 Chalcone synthase

P30074 Chalcone synthase 2

P54157 Putative chalcone synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011141	Polyketide synthase, type III
IPR001099	Chalcone/stilbene synthase, N-terminal
IPR018088	Chalcone/stilbene synthase, active site
IPR016039	Thiolase-like
IPR016038	Thiolase-like, subgroup
IPR012328	Chalcone/stilbene synthase, C-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Schroeder J, Schroeder G. Stilbene and chalcone synthases: related enzymes with key functions in plant-specific pathways. Z. Naturforsch. C 45 1-8 1990
2.	Lanz T, Tropf S, Marner FJ, Schroder J, Schroder G. The role of cysteines in polyketide synthases. Site-directed mutagenesis of resveratrol and chalcone synthases, two key enzymes in different plant-specific pathways. J. Biol. Chem. 266 9971-6 1991 [PubMed: 2033084] http://intl.jbc.org/cgi/content/abstract/266/15/9971

Additional Reading Open in usermanual
	Jez JM, Bowman ME, Noel JP. Structure-guided programming of polyketide chain-length determination in chalcone synthase. Biochemistry 40 2001 14829-38 [PubMed: 11732902] http://dx.doi.org/10.1021/bi015621z
	Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel JP. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39 2000 890-902 [PubMed: 10653632] http://dx.doi.org/10.1021/bi991489f
	Jez JM, Bowman ME, Noel JP. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc. Natl. Acad. Sci. U.S.A. 99 2002 5319-24 [PubMed: 11959984] http://dx.doi.org/10.1073/pnas.082590499
	Shomura Y, Torayama I, Suh DY, Xiang T, Kita A, Sankawa U, Miki K. Crystal structure of stilbene synthase from Arachis hypogaea. Proteins 60 2005 803-6 [PubMed: 16028220] http://dx.doi.org/10.1002/prot.20584
	Austin MB, Bowman ME, Ferrer JL, Schroder J, Noel JP. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chem. Biol. 11 2004 1179-94 [PubMed: 15380179] http://dx.doi.org/10.1016/j.chembiol.2004.05.024

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