EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR017795 Aromatic prenyltransferase, DMATS type

Protein matches Help

UniProtKB

Matches:

129 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR017795 Aromatic_prenylTrfase_DMATS

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03429	arom_pren_DMATS	129
Signatures in BioMart

InterPro Relationships Help

Children

IPR012148 Tryptophan dimethylallyltransferase

GO Term annotation Help

Process

GO:0009820 alkaloid metabolic process

Function

GO:0050364 tryptophan dimethylallyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

Proteins in this entry are mostly fungal enzymes involved in secondary metabolite production. Characterised or partially characterised members include several examples of dimethylallyltryptophan synthase, a brevianamide F prenyltransferase, LtxC from lyngbyatoxin biosynthesis, and a probable dimethylallyl tyrosine synthase [1, 2]. Tryptophan dimethylallyltransferase (EC:2.5.1.34) catalyses the first step of ergot alkaloid biosynthesis. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants.

Database links Help

Enzyme: EC:2.5.1.34

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017795

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q50EL0 Tryptophan dimethylallyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017796	Tryptophan dimethylallyltransferase, sub-group
IPR012148	Tryptophan dimethylallyltransferase
IPR017795	Aromatic prenyltransferase, DMATS type
	PDB Chain

Publications Open in usermanual
1.	Tsai HF, Wang H, Gebler JC, Poulter CD, Schardl CL. The Claviceps purpurea gene encoding dimethylallyltryptophan synthase, the committed step for ergot alkaloid biosynthesis. Biochem. Biophys. Res. Commun. 216 119-25 1995 [PubMed: 7488077] http://dx.doi.org/10.1006/bbrc.1995.2599
2.	Wang J, Machado C, Panaccione DG, Tsai HF, Schardl CL. The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass. Fungal Genet. Biol. 41 189-98 2004 [PubMed: 14732265] http://dx.doi.org/10.1016/j.fgb.2003.10.002

Additional Reading Open in usermanual
	Grundmann A, Li SM. Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. Microbiology (Reading, Engl.) 151 2005 2199-207 [PubMed: 16000710] http://dx.doi.org/10.1099/mic.0.27962-0

InterPro 23.1