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InterPro: IPR017782 Hydroxyacylglutathione hydrolase

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UniProtKB

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859 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
Matches in BioMart

Accession

IPR017782 Hydroxyacylglutathione_Hdrlase

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_01374	Hydroxyacylglutathione_Hdrlase	782
TIGRFAMs	TIGR03413	GSH_gloB	823
Signatures in BioMart

InterPro Relationships Help

Parent

IPR001279 Beta-lactamase-like

GO Term annotation Help

Function

GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0008270 zinc ion binding

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents hydroxyacylglutathione hydrolase, a detoxification enzyme also known as glyoxalase II. It follows lactoylglutathione lyase, also known as glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family.

Structural links Help

PDB - click here

SCOP: d.157.1.2

CATH: 3.60.15.10

Database links Help

Enzyme: EC:3.1.2.6

CluSTr: ALLvsALL:3431:47.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017782

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P72933 Hydroxyacylglutathione hydrolase

Q16775 Hydroxyacylglutathione hydrolase, mitochondrial

Q69ZP3 Probable hydrolase PNKD

Q8ZRM2 Hydroxyacylglutathione hydrolase

Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017782	Hydroxyacylglutathione hydrolase
IPR001279	Beta-lactamase-like
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr. Ensemble refinement of protein crystal structures: validation and application. Structure 15 2007 1040-52 [PubMed: 17850744] http://dx.doi.org/10.1016/j.str.2007.06.019
	Campos-Bermudez VA, Leite NR, Krog R, Costa-Filho AJ, Soncini FC, Oliva G, Vila AJ. Biochemical and structural characterization of Salmonella typhimurium glyoxalase II: new insights into metal ion selectivity. Biochemistry 46 2007 11069-79 [PubMed: 17764159] http://dx.doi.org/10.1021/bi7007245
	Cameron AD, Ridderstrom M, Olin B, Mannervik B. Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue. Structure 7 1999 1067-78 [PubMed: 10508780] http://dx.doi.org/10.1016/S0969-2126(99)80174-9
	Marasinghe GP, Sander IM, Bennett B, Periyannan G, Yang KW, Makaroff CA, Crowder MW. Structural studies on a mitochondrial glyoxalase II. J. Biol. Chem. 280 2005 40668-75 [PubMed: 16227621] http://dx.doi.org/10.1074/jbc.M509748200
	Kizil G, Wilks K, Wells D, Ala'Aldeen DA. Detection and characterisation of the genes encoding glyoxalase I and II from Neisseria meningitidis. J. Med. Microbiol. 49 2000 669-73 [PubMed: 10882093] http://jmm.sgmjournals.org/cgi/content/abstract/49/7/669
	O'Young J, Sukdeo N, Honek JF. Escherichia coli glyoxalase II is a binuclear zinc-dependent metalloenzyme. Arch. Biochem. Biophys. 459 2007 20-6 [PubMed: 17196158] http://dx.doi.org/10.1016/j.abb.2006.11.024

InterPro 23.1