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InterPro: IPR017749 1-pyrroline dehydrogenase

Protein matches Help

UniProtKB

Matches:

96 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR017749 1-pyrroline_dehydrogenase

Type

Family

Signatures Help

Database	ID	Name	Proteins
HAMAP	MF_01275	1-pyrroline_dehydrogenase	88
TIGRFAMs	TIGR03374	ABALDH	95
Signatures in BioMart

InterPro Relationships Help

Contains

IPR015590 Aldehyde dehydrogenase
IPR016160 Aldehyde dehydrogenase, conserved site
IPR016162 Aldehyde dehydrogenase, N-terminal

GO Term annotation Help

Process

GO:0009447 putrescine catabolic process
GO:0055114 oxidation reduction

Function

GO:0019145 aminobutyraldehyde dehydrogenase activity
GO:0051287 NAD or NADH binding

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents 1-pyrroline dehydrogenase (EC:1.2.1.19), also called gamma-aminobutyraldehyde dehydrogenase. This enzyme can follow putrescine transaminase (EC:2.6.1.82) for a two-step conversion of putrescine to gamma-aminobutyric acid (GABA). The Escherichia coli protein is characterised as a homotetramer that binds one NADH per monomer [1, 2]. This enzyme belongs to the medium-chain aldehyde dehydrogenases, and is quite similar in sequence to the betaine aldehyde dehydrogenase (EC:1.2.1.8) family.

Structural links Help

PDB - click here

SCOP: c.82.1.1

CATH: 3.40.309.10 , 3.40.605.10

Database links Help

Enzyme: EC:1.2.1.19

CluSTr: ALLvsALL:58001:233.9

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017749

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P77674 Gamma-aminobutyraldehyde dehydrogenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR015590	Aldehyde dehydrogenase
IPR017749	1-pyrroline dehydrogenase
IPR016162	Aldehyde dehydrogenase, N-terminal
IPR016161	Aldehyde/histidinol dehydrogenase
IPR016160	Aldehyde dehydrogenase, conserved site
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR. Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase. FEBS Lett. 579 4107-12 2005 [PubMed: 16023116] http://dx.doi.org/10.1016/j.febslet.2005.06.038
2.	Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C. Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase. J. Mol. Biol. 343 29-41 2004 [PubMed: 15381418] http://dx.doi.org/10.1016/j.jmb.2004.08.030

InterPro 23.1