InterPro: IPR017736 Glycoside hydrolase, family 1, beta-glucosidase

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glycoside hydrolase family 1 GH1 comprises enzymes with a number of known activities; beta-glucosidase (EC:3.2.1.21); beta-galactosidase (EC:3.2.1.23); 6-phospho-beta-galactosidase (EC:3.2.1.85); 6-phospho-beta-glucosidase (EC:3.2.1.86); lactase-phlorizin hydrolase (EC:3.2.1.62), (EC:3.2.1.108); beta-mannosidase (EC:3.2.1.25); myrosinase (EC:3.2.1.147).

This enzyme represents beta-glucosidase, which catalyses the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose [5, 6]. It has a wide substrate specificity for beta-D-glucosides.