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InterPro: IPR017682 Coenzyme F420 hydrogenase, subunit alpha

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34 proteins

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Accession List
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Accession

IPR017682 Coenz_F420_hydrogenase_asu

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03295	frhA	34
Signatures in BioMart

InterPro Relationships Help

Contains

IPR001501 Nickel-dependent hydrogenase, large subunit
IPR018194 Nickel-dependent hydrogenase, large subunit, nickel binding site

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0016151 nickel ion binding
GO:0050454 coenzyme F420 hydrogenase activity
GO:0050660 FAD binding
GO:0051536 iron-sulfur cluster binding

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents the beta subunit of coenzyme F420 hydrogenase (FRH) (EC:1.12.98.1) found exclusively and universally in methanogenic archaea [1]. Active coenzyme F420 hydrogenase forms a heterocomplex of three subunits: alpha, beta (IPR017679) and gamma (IPR017681). This enzyme reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. The enzyme complex is tightly associated with the redox cofactors: nickel, flavin adenine dinucleotide (FAD), and iron-sulphur cluster (2-13 Fe atoms per alpha/beta/gamma unit of the FRH) [2].

The N- and C-terminal domains of this protein are modelled by IPR007516 and IPR007517 respectively.

Database links Help

Enzyme: EC:1.12.98.1

CluSTr: ALLvsALL:402482:59.3

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017682

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P19496 Coenzyme F420 hydrogenase subunit alpha

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR018194	Nickel-dependent hydrogenase, large subunit, nickel binding site
IPR017682	Coenzyme F420 hydrogenase, subunit alpha
IPR001501	Nickel-dependent hydrogenase, large subunit

Publications Open in usermanual
1.	Alex LA, Reeve JN, Orme-Johnson WH, Walsh CT. Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H. Biochemistry 29 7237-44 1990 [PubMed: 2207102] http://dx.doi.org/10.1021/bi00483a011
2.	Fox JA, Livingston DJ, Orme-Johnson WH, Walsh CT. 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization. Biochemistry 26 4219-27 1987 [PubMed: 3663585] http://dx.doi.org/10.1021/bi00388a007

InterPro 23.1