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InterPro: IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y

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UniProtKB

Matches:

586 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR017597 Pyrv_DH_E1_asu_subgrp-y

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03182	PDH_E1_alph_y	586
Signatures in BioMart

InterPro Relationships Help

Contains

IPR001017 Dehydrogenase, E1 component

GO Term annotation Help

Process

GO:0006096 glycolysis
GO:0055114 oxidation reduction

Function

GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity

Component

GO:0043231 intracellular membrane-bounded organelle

InterPro annotation

Entry Details in BioMart

Abstract

Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH) [1]. This entry represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Structural links Help

PDB - click here

SCOP: c.36.1.11

CATH: 3.40.50.970

Database links Help

Enzyme: EC:1.2.4.1

CluSTr: ALLvsALL:6326:91.6

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017597

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

P16387 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

P35486 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

P52899 Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

P52901 Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017597	Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR001017	Dehydrogenase, E1 component
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Korotchkina LG, Ciszak EM, Patel MS. Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure. Arch. Biochem. Biophys. 429 171-9 2004 [PubMed: 15313220] http://dx.doi.org/10.1016/j.abb.2004.06.027

Additional Reading Open in usermanual
	Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS. Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. J. Biol. Chem. 278 2003 21240-6 [PubMed: 12651851] http://dx.doi.org/10.1074/jbc.M300339200
	Seifert F, Ciszak E, Korotchkina L, Golbik R, Spinka M, Dominiak P, Sidhu S, Brauer J, Patel MS, Tittmann K. Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex. Biochemistry 46 2007 6277-87 [PubMed: 17474719] http://dx.doi.org/10.1021/bi700083z

InterPro 23.1