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InterPro: IPR017596 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit subgroup x

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Matches:

479 proteins

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Accession

IPR017596 Pyrv_DH_E1_asu_subgrp-x

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03181	PDH_E1_alph_x	479
Signatures in BioMart

InterPro Relationships Help

Contains

IPR001017 Dehydrogenase, E1 component

GO Term annotation Help

Process

GO:0006096 glycolysis
GO:0055114 oxidation reduction

Function

GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0030976 thiamin pyrophosphate binding

InterPro annotation

Entry Details in BioMart

Abstract

Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH) [1]. This entry represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade. PDH is a heterodimer of an alpha and a beta subunit. The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and carbon dioxide. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The Bacillus subtilis PDH complex possesses also branched-chain 2-oxoacid dehydrogenase (BCDH) activity.

Structural links Help

PDB - click here

SCOP: c.36.1.11

CATH: 3.40.50.970

Database links Help

Enzyme: EC:1.2.4.1

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Overlapping InterPro entries Help

IPR017596

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P21873 Pyruvate dehydrogenase E1 component subunit alpha

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017596	Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit subgroup x
IPR001017	Dehydrogenase, E1 component
	PDB Chain
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Hawkins CF, Borges A, Perham RN. Cloning and sequence analysis of the genes encoding the alpha and beta subunits of the E1 component of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus. Eur. J. Biochem. 191 337-46 1990 [PubMed: 2200674] http://dx.doi.org/10.1111/j.1432-1033.1990.tb19128.x

Additional Reading Open in usermanual
	Frank RA, Titman CM, Pratap JV, Luisi BF, Perham RN. A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science 306 2004 872-6 [PubMed: 15514159] http://dx.doi.org/10.1126/science.1101030
	Lessard IA, Perham RN. Expression in Escherichia coli of genes encoding the E1 alpha and E1 beta subunits of the pyruvate dehydrogenase complex of Bacillus stearothermophilus and assembly of a functional E1 component (alpha 2 beta 2) in vitro. J. Biol. Chem. 269 1994 10378-83 [PubMed: 8144620]

InterPro 23.1