EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR017550 Formylmethanofuran dehydrogenase subunit C

Protein matches Help

UniProtKB

Matches:

91 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR017550 Formylmethanofuran_DH_suC

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03122	one_C_dehyd_C	91
Signatures in BioMart

InterPro Relationships Help

Parent

IPR002489 Glutamate synthase, alpha subunit, C-terminal

Found in

IPR012048 Formylmethanofuran dehydrogenase, fused subunit C/D

GO Term annotation Help

Process

GO:0015948 methanogenesis
GO:0055114 oxidation reduction

Function

GO:0018493 formylmethanofuran dehydrogenase activity
GO:0046914 transition metal ion binding

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents the C subunit of formylmethanofuran dehydrogenase (EC:1.2.99.5), which is involved in methane biosynthesis from carbon dioxide [1, 2]. This oxygen-labile enzyme catalyses the reversible oxidation of carbon dioxide and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). There is a tungsten-containing (Fwd) form of this enzyme and a molybdenum-containing (Fmd) form; this entry includes both forms [3]. Formylmethanofuran dehydrogenase is composed of 5-7 subunits, of which subunit C (FwdC or FmdC) is one. The enzymes in this entry are largely from archaeal species. Nomenclature in some bacteria may reflect inclusion of the formyltransferase described by IPR014053 as part of the complex.

Database links Help

Enzyme: EC:1.2.99.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017550

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O27002 Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit C

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017550	Formylmethanofuran dehydrogenase subunit C
IPR009010	Aspartate decarboxylase-like fold
IPR006657	Molydopterin dinucleotide-binding domain
IPR012048	Formylmethanofuran dehydrogenase, fused subunit C/D
IPR002489	Glutamate synthase, alpha subunit, C-terminal
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Deppenmeier U. The unique biochemistry of methanogenesis. Prog. Nucleic Acid Res. Mol. Biol. 71 223-83 2002 [PubMed: 12102556] http://dx.doi.org/10.1016/S0079-6603(02)71045-3
2.	Pomper BK, Vorholt JA. Characterization of the formyltransferase from Methylobacterium extorquens AM1. Eur. J. Biochem. 268 4769-75 2001 [PubMed: 11532013] http://dx.doi.org/10.1046/j.1432-1327.2001.02401.x
3.	Vorholt JA, Thauer RK. Molybdenum and tungsten enzymes in C1 metabolism. 39 571-619 2002 [PubMed: 11913137]

Additional Reading Open in usermanual
	Hochheimer A, Linder D, Thauer RK, Hedderich R. The molybdenum formylmethanofuran dehydrogenase operon and the tungsten formylmethanofuran dehydrogenase operon from Methanobacterium thermoautotrophicum. Structures and transcriptional regulation. Eur. J. Biochem. 242 1996 156-62 [PubMed: 8954165] http://dx.doi.org/10.1111/j.1432-1033.1996.0156r.x

InterPro 23.1