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InterPro: IPR017511 PQQ-dependent membrane bound dehydrogenase, glucose/quinate/shikimate related
Protein matches
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UniProtKB Matches: 300 proteins |
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Accession
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IPR017511 PQQ-dep_membr-bd_DH |
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Type
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Family |
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Signatures
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InterPro Relationships
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Contains
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IPR001479 Quinoprotein dehydrogenase, conserved site
IPR002372 Pyrrolo-quinoline quinone repeat
IPR011047 Quinonprotein alcohol dehydrogenase-like
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
IPR019551 PQQ-dependant enzyme, N-terminal
IPR019556 PQQ-dependant enzyme, C-terminal
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GO Term annotation
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Process
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GO:0055114 oxidation reduction
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Function
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GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0048038 quinone binding
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Component
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GO:0016021 integral to membrane
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InterPro annotation
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 Entry Details in BioMart
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Abstract
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This protein family has a phylogenetic distribution very similar to that of coenzyme pyrroloquinoline quinone (PQQ) biosynthesis enzymes, as shown by partial phylogenetic profiling. These proteins use PPQ as a cofactor. Members of this family have several predicted transmembrane helices in the N-terminal region, and includes:
- Quinoprotein glucose dehydrogenase (EC:1.1.5.2) of Escherichia coli, which is probably involved in energy conservation rather than in sugar metabolism [1].
- Quinate/shikimate dehydrogenase of Acinetobacter sp. (strain ADP1) (EC:1.1.99.25), which can act either on quinate or on shikimate, and is involved in the metabolism of aromatic compounds.
Sequences closely related, except for the absence of the N-terminal hydrophobic region, and not included in this entry include pyrroloquinoline quinone (PQQ)-dependent glycerol (EC:1.1.99.22) and other polyol (sugar alcohol) dehydrogenases.
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Database links
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InterPro 24.0
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