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InterPro: IPR017485 Tryptophan 2,3-dioxygenase, bacteria

Protein matches Help

UniProtKB

Matches:

197 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR017485 Trp_2-3-dOase_bac

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03036	trp_2_3_diox	197
Signatures in BioMart

InterPro Relationships Help

Parent

IPR004981 Tryptophan 2,3-dioxygenase

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0004833 tryptophan 2,3-dioxygenase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family are tryptophan 2,3-dioxygenase, as confirmed by several experimental characterizations, and by conserved operon structure for many of the other members. This enzyme represents the first of a two-step degradation to L-kynurenine, and a three-step pathway (via kynurenine) to anthranilate plus alanine.

Database links Help

Enzyme: EC:1.13.11.11

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017485

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q1LK00 Tryptophan 2,3-dioxygenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017485	Tryptophan 2,3-dioxygenase, bacteria
IPR004981	Tryptophan 2,3-dioxygenase
	PDB Chain

Publications Help

Additional Reading Open in usermanual
	Matthijs S, Baysse C, Koedam N, Tehrani KA, Verheyden L, Budzikiewicz H, Schafer M, Hoorelbeke B, Meyer JM, De Greve H, Cornelis P. The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. Mol. Microbiol. 52 2004 371-84 [PubMed: 15066027] http://dx.doi.org/10.1111/j.1365-2958.2004.03999.x
	Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A. Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS Microbiol. Lett. 227 2003 219-27 [PubMed: 14592712] http://dx.doi.org/10.1016/S0378-1097(03)00684-0

InterPro 23.1