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InterPro: IPR017484 Arylformamidase

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UniProtKB

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171 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR017484 Arylformamidase

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03035	trp_arylform	171
Signatures in BioMart

InterPro Relationships Help

Parent

IPR007325 Putative cyclase

InterPro annotation

Entry Details in BioMart

Abstract

One of several pathways of tryptophan degradation is as follows:

Tryptophan 2,3-dioxygenase (EC:1.13.11.11) uses 02 to convert Trp to L-formylkynurenine.
Arylformamidase (EC:3.5.1.9) hydrolyses the product to L-kynurenine and formate.
Kynureninase (EC:3.7.1.3) hydrolyses L-kynurenine to anthranilate plus alanine.

Members of this entry are predicted bacterial metal-dependent hydrolases. All are supported as arylformamidase (EC:3.5.1.9) by an operon structure in which kynureninase and/or tryptophan 2,3-dioxygenase genes are adjacent. The members from Bacillus cereus, Pseudomonas aeruginosa and Ralstonia metallidurans (strain CH34) have been characterised. An example from Pseudomonas fluorescens is given the gene symbol qbsH instead of kynB because of its role in quinolobactin biosynthesis, which begins with tryptophan. All members of this family should be arylformamidase (EC:3.5.1.9).

Database links Help

Enzyme: EC:3.5.1.9

CluSTr: ALLvsALL:18957:40.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017484

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0KA00 Kynurenine formamidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR017484	Arylformamidase
IPR007325	Putative cyclase
	SWISS-MODEL
	ModBase

Publications Help

Additional Reading Open in usermanual
	Matthijs S, Baysse C, Koedam N, Tehrani KA, Verheyden L, Budzikiewicz H, Schafer M, Hoorelbeke B, Meyer JM, De Greve H, Cornelis P. The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway. Mol. Microbiol. 52 2004 371-84 [PubMed: 15066027] http://dx.doi.org/10.1111/j.1365-2958.2004.03999.x
	Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A. Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS Microbiol. Lett. 227 2003 219-27 [PubMed: 14592712] http://dx.doi.org/10.1016/S0378-1097(03)00684-0

InterPro 23.1