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InterPro: IPR017476 Nucleotide sugar dehydrogenase

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2945 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR017476 Nucleotide_sugar_DH

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR03026	NDP-sugDHase	2945
Signatures in BioMart

InterPro Relationships Help

Contains

IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
IPR014028 UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain

InterPro annotation

Entry Details in BioMart

Abstract

Enzymes in this family catalyse the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (EC:1.1.1.22) [1], GDP-mannose 6-dehydrogenase (EC:1.1.1.132) [2], UDP-N-acetylglucosamine 6-dehydrogenase (EC:1.1.1.136) [3], UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase [4] and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [5]. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three domains, IPR001732, IPR014026, and IPR014027 for the N-terminal, central, and C-terminal regions respectively.

Structural links Help

PDB - click here

SCOP: a.100.1.4 , c.2.1.6 , c.26.3.1

CATH: 1.10.1040.10 , 1.20.5.100 , 3.40.50.1870 , 3.40.50.720

Database links Help

Enzyme: EC:1.1.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017476

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O02373 UDP-glucose 6-dehydrogenase

O60701 UDP-glucose 6-dehydrogenase

O70475 UDP-glucose 6-dehydrogenase

Q19905 UDP-glucose 6-dehydrogenase

Q9FM01 Probable UDP-glucose 6-dehydrogenase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
IPR016040	NAD(P)-binding domain
IPR014028	UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain
IPR014027	UDP-glucose/GDP-mannose dehydrogenase, C-terminal
IPR014026	UDP-glucose/GDP-mannose dehydrogenase, dimerisation
IPR001732	UDP-glucose/GDP-mannose dehydrogenase, N-terminal
IPR017476	Nucleotide sugar dehydrogenase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Open in usermanual
1.	Pagni M, Lazarevic V, Soldo B, Karamata D. Assay for UDPglucose 6-dehydrogenase in phosphate-starved cells: gene tuaD of Bacillus subtilis 168 encodes the UDPglucose 6-dehydrogenase involved in teichuronic acid synthesis. Microbiology (Reading, Engl.) 145 ( Pt 5) 1049-53 1999 [PubMed: 10376820]
2.	Campos M, Martinez-Salazar JM, Lloret L, Moreno S, Nunez C, Espin G, Soberon-Chavez G. Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii. J. Bacteriol. 178 1793-9 1996 [PubMed: 8606150] http://jb.asm.org/cgi/content/abstract/178/7/1793
3.	Miller WL, Wenzel CQ, Daniels C, Larocque S, Brisson JR, Lam JS. Biochemical characterization of WbpA, a UDP-N-acetyl-D-glucosamine 6-dehydrogenase involved in O-antigen biosynthesis in Pseudomonas aeruginosa PAO1. J. Biol. Chem. 279 37551-8 2004 [PubMed: 15226302] http://dx.doi.org/10.1074/jbc.M404749200
4.	Zhao X, Creuzenet C, Belanger M, Egbosimba E, Li J, Lam JS. WbpO, a UDP-N-acetyl-D-galactosamine dehydrogenase from Pseudomonas aeruginosa serotype O6. J. Biol. Chem. 275 33252-9 2000 [PubMed: 10931835] http://dx.doi.org/10.1074/jbc.M004191200
5.	Meier-Dieter U, Starman R, Barr K, Mayer H, Rick PD. Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis. J. Biol. Chem. 265 13490-7 1990 [PubMed: 2166030] http://intl.jbc.org/cgi/content/abstract/265/23/13490

Additional Reading Open in usermanual
	Snook CF, Tipton PA, Beamer LJ. Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa. Biochemistry 42 2003 4658-68 [PubMed: 12705829] http://dx.doi.org/10.1021/bi027328k
	Campbell RE, Mosimann SC, van De Rijn I, Tanner ME, Strynadka NC. The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation. Biochemistry 39 2000 7012-23 [PubMed: 10841783] http://dx.doi.org/10.1021/bi000181h

InterPro 23.1