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InterPro: IPR017380 Histone acetyltransferase type B, catalytic subunit

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93 proteins

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Accession List
Matches in BioMart

Accession

IPR017380 Hist_AcTrfase_B-typ_cat-su

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF038084	HAT-B_cat	93
Signatures in BioMart

InterPro Relationships Help

Contains

IPR013523 Histone acetyltransferase HAT1, C-terminal
IPR016181 Acyl-CoA N-acyltransferase
IPR019467 Histone acetyl transferase HAT1 N-terminal

GO Term annotation Help

Process

GO:0006348 chromatin silencing at telomere
GO:0016573 histone acetylation

Function

GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding

Component

GO:0005634 nucleus

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents the catalytic subunit of histone acetyltransferase type B (EC:2.3.1.48), which is the catalytic component of the histone acetylase B (HAT-B) complex [1, 2, 3]. The HAT-B complex is composed of at least HAT1 and HAT2. In the cytoplasm, this complex binds to the histone H4 tail. In the nucleus, the HAT-B complex has an additional component, the histone H3/H4 chaperone HIF1.

This enzyme acetylates soluble but not nucleosomal H4 at Lys-12, which is required for telomeric silencing. HAT1 has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. It is involved in DNA double-strand break repair.

Structural links Help

PDB - click here

SCOP: d.108.1.1

CATH: 1.10.10.390 , 3.40.630.30 , 3.90.360.10

Database links Help

Enzyme: EC:2.3.1.48

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR017380

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O14929 Histone acetyltransferase type B catalytic subunit

Q12341 Histone acetyltransferase type B catalytic subunit

Q6ES10 Probable acetyltransferase type B catalytic subunit

Q8BY71 Histone acetyltransferase type B catalytic subunit

Q9FJT8 Histone acetyltransferase type B catalytic subunit

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019467	Histone acetyl transferase HAT1 N-terminal
IPR016181	Acyl-CoA N-acyltransferase
IPR000182	GCN5-related N-acetyltransferase
IPR017380	Histone acetyltransferase type B, catalytic subunit
IPR013523	Histone acetyltransferase HAT1, C-terminal
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Barman HK, Takami Y, Nishijima H, Shibahara K, Sanematsu F, Nakayama T. Histone acetyltransferase-1 regulates integrity of cytosolic histone H3-H4 containing complex. Biochem. Biophys. Res. Commun. 373 624-30 2008 [PubMed: 18601901] http://dx.doi.org/10.1016/j.bbrc.2008.06.100
2.	Poveda A, Sendra R. Site specificity of yeast histone acetyltransferase B complex in vivo. FEBS J. 275 2122-36 2008 [PubMed: 18373695] http://dx.doi.org/10.1111/j.1742-4658.2008.06367.x
3.	Parthun MR. Hat1: the emerging cellular roles of a type B histone acetyltransferase. Oncogene 26 5319-28 2007 [PubMed: 17694075] http://dx.doi.org/10.1038/sj.onc.1210602

Additional Reading Open in usermanual
	Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94 1998 427-38 [PubMed: 9727486] http://dx.doi.org/10.1016/S0092-8674(00)81584-6

InterPro 23.1