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InterPro: IPR016900 Alpha-1, 2 glucosyltransferase Alg10

Protein matches Help

UniProtKB

Matches:

56 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR016900 Alpha1_2_glucosyltferase_Alg10

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF028810	Alpha1_2_glucosyltferase_Alg10	56
Signatures in BioMart

InterPro Relationships Help

Parent

IPR007006 Glycosyltransferase, ALG10

GO Term annotation Help

Function

GO:0016758 transferase activity, transferring hexosyl groups

Component

GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

Alg10p is a dolichyl-phosphoglucose-dependent glucosyltransferase which adds the terminal alpha-1,2 glucose to the lipid-linked Glc2Man9GlcNAc2 oligosaccharide. The terminal alpha-1,2-linked glucose residue is important for substrate recognition by the oligosaccharyltransferase [1]. Alpha-1,2-glucosyltransferase is a key component of the molecular pathway whereby the potassium channel regulatory protein KCR1 diminishes the cardiac repolarising current I(Kr) drug response [2].

Database links Help

Enzyme: EC:2.4.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016900

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O88788 Putative alpha-1,2-glucosyltransferase ALG10-B

P50076 Alpha-1,2 glucosyltransferase ALG10

Q10254 Alpha-1,2 glucosyltransferase alg10

Q3UGP8 Putative alpha-1,2-glucosyltransferase ALG10-B

Q5BKT4 Alpha-1,2-glucosyltransferase ALG10-A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007006	Glycosyltransferase, ALG10
IPR016900	Alpha-1, 2 glucosyltransferase Alg10
	ModBase

Publications Open in usermanual
1.	Burda P, Aebi M. The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation. Glycobiology 8 455-62 1998 [PubMed: 9597543] http://dx.doi.org/10.1093/glycob/8.5.455
2.	Nakajima T, Hayashi K, Viswanathan PC, Kim MY, Anghelescu M, Barksdale KA, Shuai W, Balser JR, Kupershmidt S. HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function. J. Biol. Chem. 282 5506-13 2007 [PubMed: 17189275] http://dx.doi.org/10.1074/jbc.M605976200

InterPro 23.1