EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR016840 Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase

Protein matches Help

UniProtKB

Matches:

124 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR016840 Glyco_hydro_43_endo_a_Ara-ase

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF026534	Endo_alpha-L-arabinosidase	124
Signatures in BioMart

InterPro Relationships Help

Parent

IPR006710 Glycoside hydrolase, family 43

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glycoside hydrolase family 43 GH43 includes enzymes with the following activities, beta-xylosidase (EC:3.2.1.37), alpha-L-arabinofuranosidase (EC:3.2.1.55); arabinanase (EC:3.2.1.99), and xylanase (EC:3.2.1.8).

This entry represents an endo-1,5-alpha-L-arabinosidase.

Structural links Help

PDB - click here

SCOP: b.67.2.1

CATH: 2.115.10.20

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016840

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P42256 Arabinan endo-1,5-alpha-L-arabinosidase A

P94522 Arabinan endo-1,5-alpha-L-arabinosidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016840	Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase
IPR006710	Glycoside hydrolase, family 43
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999

Additional Reading Open in usermanual
	Nurizzo D, Turkenburg JP, Charnock SJ, Roberts SM, Dodson EJ, McKie VA, Taylor EJ, Gilbert HJ, Davies GJ. Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold. Nat. Struct. Biol. 9 2002 665-8 [PubMed: 12198486] http://dx.doi.org/10.1038/nsb835
	Proctor MR, Taylor EJ, Nurizzo D, Turkenburg JP, Lloyd RM, Vardakou M, Davies GJ, Gilbert HJ. Tailored catalysts for plant cell-wall degradation: redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A. Proc. Natl. Acad. Sci. U.S.A. 102 2005 2697-702 [PubMed: 15708971] http://dx.doi.org/10.1073/pnas.0500051102
	Yamaguchi A, Tada T, Wada K, Nakaniwa T, Kitatani T, Sogabe Y, Takao M, Sakai T, Nishimura K. Structural basis for thermostability of endo-1,5-alpha-L-arabinanase from Bacillus thermodenitrificans TS-3. J. Biochem. 137 2005 587-92 [PubMed: 15944411] http://dx.doi.org/10.1093/jb/mvi078

InterPro 23.1