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InterPro: IPR016822 Thiopurine S-methyltransferase, subgroup

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207 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR016822 Thiopurine_S-MeTrfase_sub

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF023956	Thiopurine_S-methyltransferase	207
Signatures in BioMart

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Parent

IPR008854 Thiopurine S-methyltransferase

InterPro annotation

Entry Details in BioMart

Abstract

This group represents a thiopurine S-methyltransferase. Thiopine is commonly used to suppress the immune system in the case of autoimmune disease, inflammatory bowel disease and to prevent transplanted organ rejection [1]. Thiopurine drugs can be toxic to cells but their effect can be mediated by the incorporation of thioguanine nucleotides into DNA [2].

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PDB - click here

SCOP: c.66.1.36

CATH: 3.40.50.150

Database links Help

Enzyme: EC:2.1.1.67

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016822

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O55060 Thiopurine S-methyltransferase

O86262 Thiopurine S-methyltransferase

P51580 Thiopurine S-methyltransferase

Q17QQ2 Thiopurine S-methyltransferase

Q6C6X6 Probable thiopurine S-methyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008854	Thiopurine S-methyltransferase
IPR016822	Thiopurine S-methyltransferase, subgroup
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Gearry RB, Barclay ML, Roberts RL, Harraway J, Zhang M, Pike LS, George PM, Florkowski CM. Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice. 35 580-5 2005 [PubMed: 16207256] http://dx.doi.org/10.1111/j.1445-5994.2005.00904.x
2.	Hindorf U, Peterson C, Almer S. Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population. 26 673-8 2004 [PubMed: 15570193] http://dx.doi.org/10.1097/00007691-200412000-00014

Additional Reading Open in usermanual
	Scheuermann TH, Lolis E, Hodsdon ME. Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme. J. Mol. Biol. 333 2003 573-85 [PubMed: 14556746] http://dx.doi.org/10.1016/j.jmb.2003.08.039
	Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X. Structural basis of allele variation of human thiopurine-S-methyltransferase. Proteins 67 2007 198-208 [PubMed: 17243178] http://dx.doi.org/10.1002/prot.21272

InterPro 23.1