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InterPro: IPR016461 O-methyltransferase, COMT, eukaryota

UniProtKB

Matches:

1166 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

IPR016461 O-MeTrfase_COMT_euk

Type

Family

Signatures Help

Children

IPR014088 C-20 methyltransferase CrtF-related

Contains

IPR001077 O-methyltransferase, family 2
IPR011991 Winged helix repressor DNA-binding
IPR012967 Plant methyltransferase dimerisation

InterPro annotation

This group represents an O-methyltransferase, eukaryotic COMT type.

SCOP: a.4.5.29 , c.66.1.12

CATH: 1.10.10.10 , 3.40.50.150

Enzyme: EC:2.1.1

IPR016461

Numbers of overlapping proteins

Average numbers of overlapping amino acids

P10950 Hydroxyindole O-methyltransferase

P46597 Hydroxyindole O-methyltransferase

Q06528 Carminomycin 4-O-methyltransferase

Q6ZD89 Quercetin 3-O-methyltransferase 1

Q9FK25 Quercetin 3-O-methyltransferase 1

InterPro entry accession number/name and structure databases		Colour code
IPR011991	Winged helix repressor DNA-binding
IPR001077	O-methyltransferase, family 2
IPR016461	O-methyltransferase, COMT, eukaryota
IPR012967	Plant methyltransferase dimerisation
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Additional Reading Open in usermanual
	Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell 18 2006 3656-69 [PubMed: 17172354] http://dx.doi.org/10.1105/tpc.106.041376
	Jansson A, Niemi J, Lindqvist Y, Mantsala P, Schneider G. Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. J. Mol. Biol. 334 2003 269-80 [PubMed: 14607118] http://dx.doi.org/10.1016/j.jmb.2003.09.061
	Jansson A, Koskiniemi H, Erola A, Wang J, Mantsala P, Schneider G, Niemi J. Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor. J. Biol. Chem. 280 2005 3636-44 [PubMed: 15548527] http://dx.doi.org/10.1074/jbc.M412095200
	Jansson A, Koskiniemi H, Mantsala P, Niemi J, Schneider G. Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products. J. Biol. Chem. 279 2004 41149-56 [PubMed: 15273252] http://dx.doi.org/10.1074/jbc.M407081200
	Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell 14 2002 1265-77 [PubMed: 12084826] http://dx.doi.org/10.1105/tpc.001412

InterPro 23.1