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InterPro: IPR016434 Ribonuclease P, protein component 2

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UniProtKB

Matches:

25 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR016434 RNase_P_comp-2

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF004952	RNase_P_2	25
Signatures in BioMart

InterPro Relationships Help

Parent

IPR002759 Ribonuclease P-related

GO Term annotation Help

Process

GO:0001682 tRNA 5'-leader removal

Function

GO:0004526 ribonuclease P activity

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents protein component 2 of ribonuclease (RNase) P (EC:3.1.26.5). RNase P is a protein complex that functions in the processing of pre-tRNA, generating mature tRNA molecules by cleaving their 5'-ends; it consists of a RNA moiety and at least 4 protein subunits. Unlike most other natural ribozymes, it recognises and cleaves its substrate in trans [1].

Structural links Help

PDB - click here

SCOP: d.58.59.1

Database links Help

Enzyme: EC:3.1.26.5

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016434

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O59150 Ribonuclease P protein component 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002759	Ribonuclease P-related
IPR016434	Ribonuclease P, protein component 2
	PDB Chain
	SCOP Domain

Publications Open in usermanual
1.	Torres-Larios A, Swinger KK, Pan T, Mondragon A. Structure of ribonuclease P--a universal ribozyme. Curr. Opin. Struct. Biol. 16 327-35 2006 [PubMed: 16650980] http://dx.doi.org/10.1016/j.sbi.2006.04.002

Additional Reading Open in usermanual
	Kawano S, Nakashima T, Kakuta Y, Tanaka I, Kimura M. Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme. J. Mol. Biol. 357 2006 583-91 [PubMed: 16430919] http://dx.doi.org/10.1016/j.jmb.2005.12.086
	Wilson RC, Bohlen CJ, Foster MP, Bell CE. Structure of Pfu Pop5, an archaeal RNase P protein. Proc. Natl. Acad. Sci. U.S.A. 103 2006 873-8 [PubMed: 16418270] http://dx.doi.org/10.1073/pnas.0508004103

InterPro 23.1