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InterPro: IPR016365 Actobindin

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UniProtKB

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5 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR016365 Actobindin

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF002724	Actobindin	5
Signatures in BioMart

InterPro Relationships Help

Contains

IPR003124 Actin-binding WH2

InterPro annotation

Entry Details in BioMart

Abstract

This group represents an actobindin; a 9.8kDa protein from Acanthamoeba castellanii [1]. It belongs to a group of G-actin binding proteins including actobindin, twinfilin, and profilin [2]. Actobindin consists of two beta-thymosin repeats [3]. It inhibits nucleation of new actin filaments and facilitates elongation of existing polarized filaments in actively motile regions [4]. Actobindin does not form a stable complex with actin dimers but causes the accumulation of dimers that are unable to nucleate polymerisation or self-associate [5].

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016365

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P18281 Actobindin

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016365	Actobindin

Publications Open in usermanual
1.	Bubb MR, Lewis MS, Korn ED. Actobindin binds with high affinity to a covalently cross-linked actin dimer. J. Biol. Chem. 269 25587-91 1994 [PubMed: 7929261] http://intl.jbc.org/cgi/reprint/269/41/25587.pdf
2.	Arasada R, Gloss A, Tunggal B, Joseph JM, Rieger D, Mondal S, Faix J, Schleicher M, Noegel AA. Profilin isoforms in Dictyostelium discoideum. Biochim. Biophys. Acta 1773 631-41 2007 [PubMed: 17467078] http://dx.doi.org/10.1016/j.bbamcr.2007.03.009
3.	Hertzog M, Yarmola EG, Didry D, Bubb MR, Carlier MF. Control of actin dynamics by proteins made of beta-thymosin repeats: the actobindin family. J. Biol. Chem. 277 14786-92 2002 [PubMed: 11856744] http://dx.doi.org/10.1074/jbc.M112064200
4.	Bubb MR, Baines IC, Korn ED. Localization of actobindin, profilin I, profilin II, and phosphatidylinositol-4,5-bisphosphate (PIP2) in Acanthamoeba castellanii. Cell Motil. Cytoskeleton 39 134-46 1998 [PubMed: 9484955] http://dx.doi.org/10.1002/(SICI)1097-0169(1998)39:2<134::AID-CM4>3.0.CO;2-6
5.	Bubb MR, Knutson JR, Porter DK, Korn ED. Actobindin induces the accumulation of actin dimers that neither nucleate polymerization nor self-associate. J. Biol. Chem. 269 25592-7 1994 [PubMed: 7929262] http://intl.jbc.org/cgi/reprint/269/41/25592.pdf

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