InterPro: IPR016331 Shiga-like toxin, subunit A

This entry represents subunit A of Shiga-like toxin also known as rRNA N-glycosidase; EC:3.2.2.22), which are responsible for inactivation of the ribosome. Shiga-like toxins are produced by Shigella dysenteriae and by bacteriophage that infect Escherichia coli cells [1]. These toxins contain a single A subunit that has N-glycosidase activity and multiple copies of the B subunit that binds to the membrane glycolipid, globotriaosylceramide (Gb3). The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. It catalyses the endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.