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InterPro: IPR016303 3-dehydroquinate synthase

Protein matches Help

UniProtKB

Matches:

1563 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR016303 DHQ_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF001455	DHQ_synth	1563
Signatures in BioMart

InterPro Relationships Help

Contains

IPR016037 3-dehydroquinate synthase AroB, subgroup

GO Term annotation Help

Process

GO:0009058 biosynthetic process

Function

GO:0016838 carbon-oxygen lyase activity, acting on phosphates

InterPro annotation

Entry Details in BioMart

Abstract

Dehydroquinate synthase is an enzyme encoded by aroB. It is the second enzyme in the shikimate pathway, catalysing the cyclization of 3-deoxy-D-arabino-heptulosonate-7-phosphate in 3-dehydroquinate [1, 2, 3]. Since the shikimate pathway is vital for pathenogenic virulence in bacteria (including Mycobacterium tuberculosis) and fungi but not in mammals, it is an important target for the development of antifungal and antibacterial agents.

Structural links Help

PDB - click here

SCOP: e.22.1.1

CATH: 1.20.1090.10 , 3.40.50.1970

Database links Help

Enzyme: EC:4.2.3.4

CluSTr: ALLvsALL:31178:69.2

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR016303

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A1RVE1 3-dehydroquinate synthase

A2BQG2 3-dehydroquinate synthase

P56081 3-dehydroquinate synthase

P73997 3-dehydroquinate synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016303	3-dehydroquinate synthase
IPR002658	3-dehydroquinate synthase AroB
IPR016037	3-dehydroquinate synthase AroB, subgroup
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	de Mendonca JD, Ely F, Palma MS, Frazzon J, Basso LA, Santos DS. Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification. J. Bacteriol. 189 6246-52 2007 [PubMed: 17586643] http://dx.doi.org/10.1128/JB.00425-07
2.	Sugahara M, Nodake Y, Sugahara M, Kunishima N. Crystal structure of dehydroquinate synthase from Thermus thermophilus HB8 showing functional importance of the dimeric state. Proteins 58 249-52 2005 [PubMed: 15508124] http://dx.doi.org/10.1002/prot.20281
3.	Bereswill S, Fassbinder F, Volzing C, Haas R, Reuter K, Ficner R, Kist M. Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori. Med. Microbiol. Immunol. 186 125-34 1997 [PubMed: 9403840] http://dx.doi.org/10.1007/s004300050054

InterPro 23.1