InterPro: IPR016270 Phospholipase D, phosphatidylserine synthase type

This entry represents phospholipase D enzymes, such as phosphatidylserine synthase (PSS, or CDP-diacylglycerol--serine O-phosphatidyltransferase; EC:2.7.8.8) and phosphatidylglycerophosphate synthase (PGPS or CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC:2.7.8.5). Both these enzymes play essential roles in the regulation of membrane lipids. Membrane lipids are required for multiple roles ranging from messenger roles in signal transduction pathways to a role as substrate for many enzymes. PSS catalyses the convertion of CDP-diacylglycerol and L-serine to CMP and phosphatidylserine. PSS can be found in both eukaryotes and prokaryotes. In mammals, phosphatidylserine is produced through the exchange of L-serine with the base moieties of phosphatidylcholine (PSS 1) and phosphatidylethanolamine (PSS 2) [1]. In Escherichia coli, the phosphatidylserine synthesised by PSS is rapidly converted to phosphatidylethanolamine [2]. PGPS catalyses the conversion of CDP-diacylglycerol and glycerol 3-phosphate to CMP and phosphatidylglycerol.