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InterPro: IPR016090 Phospholipase A2
Protein matches
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UniProtKB Matches: 1269 proteins |
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Accession
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IPR016090 Phospholipase_A2 |
Type
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Domain |
Signatures
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InterPro Relationships
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Found in
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IPR001211 Phospholipase A2, eukaryotic
IPR008774 Phospholipase A2, metazoa
IPR010711 Phospholipase A2, group XII secretory
IPR015141 Phospholipase A2, prokaryotic/fungal
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Contains
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IPR013090 Phospholipase A2, active site
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InterPro annotation
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Entry Details in BioMart
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Abstract
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This entry represents eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; EC:3.1.1.4), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides.
The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [1, 2]. In eukaryotes, PLAS plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation.
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Structural links
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Database links
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Additional Reading
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Marchi-Salvador DP, Correa LC, Magro AJ, Oliveira CZ, Soares AM, Fontes MR.
Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom.
Proteins 72 2008 883-91
[PubMed: 18275084]
http://dx.doi.org/10.1002/prot.21980
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Murakami MT, Kuch U, Betzel C, Mebs D, Arni RK.
Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus.
Toxicon 51 2008 723-35
[PubMed: 18295812]
http://dx.doi.org/10.1016/j.toxicon.2007.11.018
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Hu P, Sun L, Zhu ZQ, Hou XW, Wang S, Yu SS, Wang HL, Zhang P, Wang M, Niu LW, Teng MK, Ruan DY.
Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents.
Proteins 72 2008 673-83
[PubMed: 18247353]
http://dx.doi.org/10.1002/prot.21964
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Correa LC, Marchi-Salvador DP, Cintra AC, Sampaio SV, Soares AM, Fontes MR.
Crystal structure of a myotoxic Asp49-phospholipase A2 with low catalytic activity: Insights into Ca2+-independent catalytic mechanism.
Biochim. Biophys. Acta 1784 2008 591-9
[PubMed: 18261474]
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Zhou X, Tan TC, Valiyaveettil S, Go ML, Kini RM, Velazquez-Campoy A, Sivaraman J.
Structural characterization of myotoxic ecarpholin S from Echis carinatus venom.
Biophys. J. 95 2008 3366-80
[PubMed: 18586854]
http://dx.doi.org/10.1529/biophysj.107.117747
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InterPro 23.1
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