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InterPro: IPR015977 Nicotinate phosphoribosyltransferase-like

Protein matches Help

UniProtKB

Matches:

1624 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015977 Nic_PRibTrfase-like

Secondary

IPR007229

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04095	NAPRTase	1624
Signatures in BioMart

InterPro Relationships Help

Children

IPR007229 Nicotinate phosphoribosyltransferase-related
IPR016471 Nicotinamide phosphoribosyl transferase

InterPro annotation

Entry Details in BioMart

Abstract

Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate-limiting enzyme that catalyses the first reaction in the NAD salvage synthesis. This family also contains a number of closely related proteins for which a catalytic activity has not been experimentally demonstrated.

Structural links Help

PDB - click here

SCOP: c.1.17.1 , c.1.17.2

CATH: 3.20.140.10

Database links Help

Enzyme: EC:2.4.2.11

PANDIT: PF04095

Pfam Clan: CL0036.20

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR015977

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P39683 Nicotinate phosphoribosyltransferase

P43490 Nicotinamide phosphoribosyltransferase

Q95XX1 Nicotinate phosphoribosyltransferase

Q99KQ4 Nicotinamide phosphoribosyltransferase

Q9VQX4 Nicotinate phosphoribosyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006406	Nicotinate phosphoribosyltransferase
IPR006405	Nicotinate phosphoribosyltransferase putative
IPR007229	Nicotinate phosphoribosyltransferase-related
IPR015977	Nicotinate phosphoribosyltransferase-like
IPR016471	Nicotinamide phosphoribosyl transferase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Chappie JS, Canaves JM, Han GW, Rife CL, Xu Q, Stevens RC. The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure 13 2005 1385-96 [PubMed: 16154095] http://dx.doi.org/10.1016/j.str.2005.05.016
	Dulyaninova NG, Podlepa EM, Toulokhonova1 LV, Bykhovsky VY. Salvage pathway for NAD biosynthesis in Brevibacterium ammoniagenes: regulatory properties of triphosphate-dependent nicotinate phosphoribosyltransferase. Biochim. Biophys. Acta 1478 2000 211-20 [PubMed: 10825532] http://dx.doi.org/10.1016/S0167-4838(00)00045-5

InterPro 23.1