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InterPro: IPR015943 WD40/YVTN repeat-like-containing domain
Protein matches
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UniProtKB Matches: 32873 proteins |
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Accession
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IPR015943 WD40/YVTN_repeat-like_dom |
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Type
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Domain |
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Signatures
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InterPro Relationships
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Children
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IPR001627 Semaphorin/CD100 antigen
IPR011045 Nitrous oxide reductase, N-terminal
IPR011046 WD40 repeat-like-containing domain
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Found in
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IPR004083 Regulatory associated protein of TOR
IPR008311 Uncharacterised conserved protein UCP028101
IPR008826 Selenium-binding protein
IPR011400 Translation initiation factor eIF-3b
IPR012393 Peptidase S41B, tricorn core peptidase
IPR013476 Methylamine dehydrogenase heavy chain
IPR016346 Guanine nucleotide-binding protein, beta subunit
IPR016391 Coatomer, alpha subunit
IPR016453 Coatomer, beta' subunit
IPR017169 Anaphase-promoting complex, subunit 4
IPR017217 BLOC-2 complex, Hps5 subunit
IPR017233 WD repeat protein 35
IPR017251 Apoptotic protease-activating factor 1
IPR017252 Dynein regulator
IPR017383 Actin-related protein 2/3 complex, subunit 1
IPR017399 WD repeat protein 23
IPR017422 WD repeat protein 55
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Contains
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IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR011964 YVTN beta-propeller repeat
IPR013577 Lethal giant larvae homologue 2
IPR013979 Eukaryotic translation initiation factor 2A, central region
IPR014908 Nup133, N-terminal
IPR018067 Protein phosphatase 2A, regulatory subunit PR55, conserved site
IPR019405 Domain of unknown function DUF2394
IPR019417 Protein of unknown function DUF2415
IPR019578 Serine-threonine phosphatase 2A, subunit B, alpha/ beta central domain
IPR019775 WD40 repeat, conserved site
IPR019781 WD40 repeat, subgroup
IPR019782 WD40 repeat 2
IPR020389 Aggregative adherence fimbria I, AAF/I
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InterPro annotation
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 Entry Details in BioMart
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Abstract
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This entry represents a WD40/YVTN repeat-like domain. Both the WD40 and the YVTN repeated motifs consist of about 40 residues, and although they consist of distinct sequences, they do share a similar structure. Structurally, both the WD40 and the YVTN repeated motifs form seven-bladed propellers (although some members can contain eight blades), which consist of seven 4-stranded beta-sheets.
The WD40-type repeat domain is found in the beta-1 subunit of the signal-transducing G protein [1], in yeast Tup1 protein [2], in Groucho [3], in the yeast cell cycle protein Cdc4 [4] and in actin-interacting protein 1 [5].
The YVTN-type repeat domain is found in archaeal surface layer proteins (SLPs) that protect cells from extreme environments [6], in quinohemoprotein amine dehydrogenase (QHNDH) [7], and in methylamine dehydrogenase [8].
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Structural links
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SCOP:
b.69.10.1
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b.69.11.1
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b.69.12.1
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b.69.14.1
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b.69.2.1
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b.69.2.2
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b.69.2.3
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b.69.3.1
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b.69.4.1
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b.69.4.2
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b.69.9.1
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Interactions
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This domain has been experimentally proven to be involved in Protein:Protein interactions. Representative
data is shown with the following
example proteins:
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Publications
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1.
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Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB.
A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin.
Mol. Cell 3 649-60 1999
[PubMed: 10360181]
http://dx.doi.org/10.1016/S1097-2765(00)80358-5
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2.
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Sprague ER, Redd MJ, Johnson AD, Wolberger C.
Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.
EMBO J. 19 3016-27 2000
[PubMed: 10856245]
http://dx.doi.org/10.1093/emboj/19.12.3016
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3.
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Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH.
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.
Structure 10 751-61 2002
[PubMed: 12057191]
http://dx.doi.org/10.1016/S0969-2126(02)00768-2
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4.
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Orlicky S, Tang X, Willems A, Tyers M, Sicheri F.
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.
Cell 112 243-56 2003
[PubMed: 12553912]
http://dx.doi.org/10.1016/S0092-8674(03)00034-5
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5.
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Mohri K, Vorobiev S, Fedorov AA, Almo SC, Ono S.
Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
J. Biol. Chem. 279 31697-707 2004
[PubMed: 15150269]
http://dx.doi.org/10.1074/jbc.M403351200
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6.
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Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA.
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.
Structure 10 1453-64 2002
[PubMed: 12377130]
http://dx.doi.org/10.1016/S0969-2126(02)00840-7
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8.
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Chen L, Doi M, Durley RC, Chistoserdov AY, Lidstrom ME, Davidson VL, Mathews FS.
Refined crystal structure of methylamine dehydrogenase from Paracoccus denitrificans at 1.75 A resolution.
J. Mol. Biol. 276 131-49 1998
[PubMed: 9514722]
http://dx.doi.org/10.1006/jmbi.1997.1511
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Additional Reading
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Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J.
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nat. Struct. Mol. Biol. 15 2008 155-62
[PubMed: 18204463]
http://dx.doi.org/10.1038/nsmb.1377
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Johnston CA, Kimple AJ, Giguere PM, Siderovski DP.
Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
Structure 16 2008 1086-94
[PubMed: 18611381]
http://dx.doi.org/10.1016/j.str.2008.04.010
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Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP.
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
Mol. Cell 26 2007 131-43
[PubMed: 17434132]
http://dx.doi.org/10.1016/j.molcel.2007.02.022
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Nolen BJ, Pollard TD.
Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex.
Mol. Cell 26 2007 449-57
[PubMed: 17499050]
http://dx.doi.org/10.1016/j.molcel.2007.04.017
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Favory JJ, Stec A, Gruber H, Rizzini L, Oravecz A, Funk M, Albert A, Cloix C, Jenkins GI, Oakeley EJ, Seidlitz HK, Nagy F, Ulm R.
Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis.
EMBO J. 28 2009 591-601
[PubMed: 19165148]
http://dx.doi.org/10.1038/emboj.2009.4
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Larsen NA, Al-Bassam J, Wei RR, Harrison SC.
Structural analysis of Bub3 interactions in the mitotic spindle checkpoint.
Proc. Natl. Acad. Sci. U.S.A. 104 2007 1201-6
[PubMed: 17227844]
http://dx.doi.org/10.1073/pnas.0610358104
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