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InterPro: IPR015890 Chorismate binding, C-terminal

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UniProtKB

Matches:

4405 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015890 Chorismate-bd_C

Secondary

IPR000350 , IPR005801

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00425	Chorismate_bind	4405
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004561 Isochorismate synthase
IPR005256 Anthranilate synthase component I
IPR005257 Anthranilate synthase component I, TrpE
IPR005801 ADC synthase
IPR005802 Para-aminobenzoate synthase, component I
IPR010112 Anthranilate synthase, clad 3
IPR010116 Anthranilate synthase component I, archaeal
IPR010117 Para-aminobenzoate synthase
IPR010118 Para-aminobenzoate synthase/anthranilate synthase, component I
IPR019996 Salicylate synthase

Contains

IPR019999 Anthranilate synthase component I, C-terminal

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction:

chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate.

The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity IPR006220.

Structural links Help

PDB - click here

SCOP: d.161.1.1

CATH: 3.60.120.10

Database links Help

PANDIT: PF00425

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR015890

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00897 Anthranilate synthase component 1

P00899 Anthranilate synthase component 1

P20170 Probable anthranilate synthase component 1

P32068 Anthranilate synthase component I-1, chloroplastic

Q06128 Anthranilate synthase component 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019999	Anthranilate synthase component I, C-terminal
IPR010116	Anthranilate synthase component I, archaeal
IPR006805	Anthranilate synthase component I, N-terminal
IPR005801	ADC synthase
IPR015890	Chorismate binding, C-terminal
IPR005256	Anthranilate synthase component I
IPR005257	Anthranilate synthase component I, TrpE
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Parsons JF, Shi KM, Ladner JE. Structure of isochorismate synthase in complex with magnesium. Acta Crystallogr. D Biol. Crystallogr. 64 2008 607-10 [PubMed: 18453696] http://dx.doi.org/10.1107/S0907444908005477
	Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate. J. Mol. Biol. 357 2006 524-34 [PubMed: 16434053] http://dx.doi.org/10.1016/j.jmb.2005.12.078
	Dosselaere F, Vanderleyden J. A metabolic node in action: chorismate-utilizing enzymes in microorganisms. Crit. Rev. Microbiol. 27 2001 75-131 [PubMed: 11450855]
	Harrison AJ, Yu M, Gardenborg T, Middleditch M, Ramsay RJ, Baker EN, Lott JS. The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J. Bacteriol. 188 2006 6081-91 [PubMed: 16923875] http://dx.doi.org/10.1128/JB.00338-06
	Spraggon G, Kim C, Nguyen-Huu X, Yee MC, Yanofsky C, Mills SE. The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan. Proc. Natl. Acad. Sci. U.S.A. 98 2001 6021-6 [PubMed: 11371633] http://dx.doi.org/10.1073/pnas.111150298
	Parsons JF, Jensen PY, Pachikara AS, Howard AJ, Eisenstein E, Ladner JE. Structure of Escherichia coli aminodeoxychorismate synthase: architectural conservation and diversity in chorismate-utilizing enzymes. Biochemistry 41 2002 2198-208 [PubMed: 11841211] http://dx.doi.org/10.1021/bi015791b
	Zwahlen J, Kolappan S, Zhou R, Kisker C, Tonge PJ. Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis. Biochemistry 46 2007 954-64 [PubMed: 17240979] http://dx.doi.org/10.1021/bi060852x

InterPro 23.1