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InterPro: IPR015815 3-hydroxyacid dehydrogenase/reductase

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UniProtKB

Matches:

3482 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015815 3hydroxyacid_DH/Rdtase

Secondary

IPR002204

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR22981	3hydroxy_acid_DH	3482
Signatures in BioMart

InterPro Relationships Help

Found in

IPR006183 6-phosphogluconate dehydrogenase
IPR006398 2-hydroxy-3-oxopropionate reductase
IPR011548 3-hydroxyisobutyrate dehydrogenase

Contains

IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site
IPR006115 6-phosphogluconate dehydrogenase, NAD-binding
IPR013328 Dehydrogenase, multihelical

InterPro annotation

Entry Details in BioMart

Abstract

This family contains related reductases/dehydrogenases.

3-hydroxyisobutyrate dehydrogenase (EC:1.1.1.31) catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate [1]. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa [2] (gene mmsB), it is involved in the distal valine metabolic pathway.
2-hydroxy-3-oxopropionate reductase (EC:1.1.1.60) catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate.
6-phosphogluconate dehydrogenase (EC:1.1.1.44) catalyzes the NADP-dependent decarboxylation of 6-phosphogluconate to D-ribulose 5-phosphate and CO₂.

Structural links Help

PDB - click here

SCOP: a.100.1.1 , c.2.1.6

CATH: 1.10.1040.10 , 3.40.50.720

Database links Help

Enzyme: EC:1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR015815

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial

Q8T079 Putative oxidoreductase GLYR1 homolog

Q922P9 Putative oxidoreductase GLYR1

Q9SUC0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

Q9XTI0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR000313	PWWP
IPR002204	3-hydroxyisobutyrate dehydrogenase-related, conserved site
IPR017956	AT hook, DNA-binding motif
IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
IPR016040	NAD(P)-binding domain
IPR015815	3-hydroxyacid dehydrogenase/reductase
IPR006115	6-phosphogluconate dehydrogenase, NAD-binding
IPR006183	6-phosphogluconate dehydrogenase
IPR013328	Dehydrogenase, multihelical
IPR011548	3-hydroxyisobutyrate dehydrogenase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL

Publications Open in usermanual
1.	Rougraff PM, Zhang B, Kuntz MJ, Harris RA, Crabb DW. Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. J. Biol. Chem. 264 5899-903 1989 [PubMed: 2647728] http://intl.jbc.org/cgi/reprint/264/10/5899.pdf
2.	Steele MI, Lorenz D, Hatter K, Park A, Sokatch JR. Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase. J. Biol. Chem. 267 13585-92 1992 [PubMed: 1339433] http://intl.jbc.org/cgi/reprint/267/19/13585.pdf

Additional Reading Open in usermanual
	Lokanath NK, Ohshima N, Takio K, Shiromizu I, Kuroishi C, Okazaki N, Kuramitsu S, Yokoyama S, Miyano M, Kunishima N. Crystal structure of novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8. J. Mol. Biol. 352 2005 905-17 [PubMed: 16126223] http://dx.doi.org/10.1016/j.jmb.2005.07.068
	Osipiuk J, Zhou M, Moy S, Collart F, Joachimiak A. X-Ray crystal structure of GarR-tartronate semialdehyde reductase from Salmonella typhimurium. J. Struct. Funct. Genomics 2009 [PubMed: 19184529]

InterPro 23.1