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InterPro: IPR015520 Imaginal disc growth factor

Protein matches Help

UniProtKB

Matches:

200 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015520 Imaginal_disc_gf

Type

Family

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR11177:SF25	Imaginal_disc_gf	200
Signatures in BioMart

InterPro Relationships Help

Contains

IPR011583 Chitinase II

InterPro annotation

Entry Details in BioMart

Abstract

Imaginal disc growth factors are soluble factors involved in the regulation of proliferation in imaginal discs. They were discovered in Drosophila melanogaster (Fruit fly), and orthologs appear in Bombyx mori (Silk moth) among others; similar glycoproteins of unknown function have also been found in mammals. IDGFs are structurally related to chitinases, although they have no catalytic activity and appear to act as lectins [1].

Structural links Help

PDB - click here

SCOP: c.1.8.5 , d.26.3.1

CATH: 3.10.50.10 , 3.20.20.80

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR015520

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P27050 Chitinase D

Q2PQM6 Chitinase-like protein Idgf5

Q9V3D4 Chitinase-like protein Idgf2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR015520	Imaginal disc growth factor
IPR001579	Glycoside hydrolase, chitinase active site
IPR008957	Fibronectin, type III-like fold
IPR003610	Carbohydrate-binding domain, family 5/12
IPR017853	Glycoside hydrolase, catalytic core
IPR011583	Chitinase II
IPR003961	Fibronectin, type III
IPR003962	Fibronectin, type III subdomain
IPR001223	Glycoside hydrolase, family 18, catalytic domain
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Bryant PJ. Growth factors controlling imaginal disc growth in Drosophila. Novartis Found. Symp. 237 182-94; discussion 194-202 2001 [PubMed: 11444043]

Additional Reading Open in usermanual
	Varela PF, Llera AS, Mariuzza RA, Tormo J. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. J. Biol. Chem. 277 2002 13229-36 [PubMed: 11821393] http://dx.doi.org/10.1074/jbc.M110502200

InterPro 23.1