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InterPro: IPR015510 Peptidoglycan recognition protein

Protein matches Help

UniProtKB

Matches:

1025 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015510 PGRP

Type

Domain

Signatures Help

Database	ID	Name	Proteins
PANTHER	PTHR11022	PGRPs	1025
Signatures in BioMart

InterPro Relationships Help

Parent

IPR002502 N-acetylmuramoyl-L-alanine amidase, family 2

Children

IPR006619 Peptidoglycan recognition protein, metazoa/bacteria

GO Term annotation Help

Process

GO:0009253 peptidoglycan catabolic process

Function

GO:0008745 N-acetylmuramoyl-L-alanine amidase activity

InterPro annotation

Entry Details in BioMart

Abstract

This is a group of animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme [1]. The bacteriophage molecule, but not its moth homologue, has been shown to have N-acetylmuramoyl-L-alanine amidase activity. One member, Tag7, is a cytokine [2].

Structural links Help

PDB - click here

SCOP: d.118.1.1

CATH: 3.40.80.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR015510

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A1A547 Peptidoglycan recognition protein I-alpha

O05071 Uncharacterized protein HI1494

O75594 Peptidoglycan recognition protein

P00806 N-acetylmuramoyl-L-alanine amidase

Q8INK6 Peptidoglycan-recognition protein LB

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002502	N-acetylmuramoyl-L-alanine amidase, family 2
IPR006619	Peptidoglycan recognition protein, metazoa/bacteria
IPR018247	EF-Hand 1, calcium-binding site
IPR015510	Peptidoglycan recognition protein
IPR017331	Peptidoglycan recognition protein, PGRP-S
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Kang D, Liu G, Lundstrom A, Gelius E, Steiner H. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc. Natl. Acad. Sci. U.S.A. 95 10078-82 1998 [PubMed: 9707603] http://dx.doi.org/10.1073/pnas.95.17.10078
2.	Kiselev SL, Kustikova OS, Korobko EV, Prokhortchouk EB, Kabishev AA, Lukanidin EM, Georgiev GP. Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine. J. Biol. Chem. 273 18633-9 1998 [PubMed: 9660837] http://dx.doi.org/10.1074/jbc.273.29.18633

Additional Reading Open in usermanual
	Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA. Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci. 15 2006 1199-206 [PubMed: 16641493] http://dx.doi.org/10.1110/ps.062077606
	Lim JH, Kim MS, Kim HE, Yano T, Oshima Y, Aggarwal K, Goldman WE, Silverman N, Kurata S, Oh BH. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. J. Biol. Chem. 281 2006 8286-95 [PubMed: 16428381] http://dx.doi.org/10.1074/jbc.M513030200
	Guan R, Wang Q, Sundberg EJ, Mariuzza RA. Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution. J. Mol. Biol. 347 2005 683-91 [PubMed: 15769462] http://dx.doi.org/10.1016/j.jmb.2005.01.070
	Chang CI, Ihara K, Chelliah Y, Mengin-Lecreulx D, Wakatsuki S, Deisenhofer J. Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Proc. Natl. Acad. Sci. U.S.A. 102 2005 10279-84 [PubMed: 16006509] http://dx.doi.org/10.1073/pnas.0504547102
	Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Science 311 2006 1761-4 [PubMed: 16556841] http://dx.doi.org/10.1126/science.1123056

InterPro 24.0