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InterPro: IPR015338 EXTL2, alpha-1,4-N-acetylhexosaminyltransferase

Protein matches Help

UniProtKB

Matches:

238 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR015338 HexNAc_Trfase_a

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF09258	Glyco_transf_64	238
Signatures in BioMart

GO Term annotation Help

Function

GO:0016758 transferase activity, transferring hexosyl groups

Component

GO:0031227 intrinsic to endoplasmic reticulum membrane

InterPro annotation

Entry Details in BioMart

Abstract

Members of this entry catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analogue of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate [1].

Structural links Help

PDB - click here

SCOP: c.68.1.15

CATH: 3.90.550.10

Database links Help

Enzyme: EC:2.4.1

Pfam Clan: CL0110.8

Taxonomic coverage Help

Example proteins Help

A5D7I4 Exostosin-1

O01705 Exostosin-2

O43909 Exostosin-like 3

Q9ES89 Exostosin-like 2

Q9V730 Exostosin-1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR015338	EXTL2, alpha-1,4-N-acetylhexosaminyltransferase
IPR004263	Exostosin-like
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Pedersen LC, Dong J, Taniguchi F, Kitagawa H, Krahn JM, Pedersen LG, Sugahara K, Negishi M. Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. J. Biol. Chem. 278 14420-8 2003 [PubMed: 12562774] http://dx.doi.org/10.1074/jbc.M210532200

InterPro 23.1