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InterPro: IPR014766 Carboxypeptidase, regulatory domain

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UniProtKB

Matches:

1165 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR014766 CarboxyPept_regulatory_dom

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:2.60.40.1120	CarboxyPept_regulatory	1165
Signatures in BioMart

InterPro Relationships Help

Parent

IPR008969 Carboxypeptidase-like, regulatory domain

Found in

IPR012103 Peptidase S8A, bacillopeptidase F
IPR014501 Uncharacterised conserved protein UCP019317
IPR015567 Peptidase M14B, caboxypeptidase D unit2

GO Term annotation Help

Function

GO:0004180 carboxypeptidase activity

InterPro annotation

Entry Details in BioMart

Abstract

This domain identifies a number of eukaryotic carboxypeptidases, these include carboxypeptidase D, E (H), N, X, X2 and Z. These are metallopeptidases belong to MEROPS peptidase family M14 (clan MC), subfamily M14B.

Carboxypeptidase D (CPD) is a new B-type metallocarboxypeptidase that is membrane bound and has an acidic pH optimum. A hydrophobic region at the N terminus represents the signal peptide, and one near the C terminus that probably represents the transmembrane anchor. A regulatory domain within the protein has been identified as a beta-sandwich, comprising 7 strands in 2 sheets in a greek-key topology. Some family members have an additional 1-2 strands to the common fold [1].

The bacterial and archaeal sequences having this signature are variously annotated, examples are:

Hypothetical/conserved/membrane/cell surface protein
N-acetylglucosamine deacetylase
Side tail fibre protein homologue from lambdoid prophage Rac
Hypothetical tonB-linked outer membrane receptor
OmpA-related protein
Putative outer membrane protein, probably involved in nutrient binding
TonB-dependent receptor

Structural links Help

PDB - click here

SCOP: b.3.2.1

CATH: 2.60.40.1120

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR014766

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O89001 Carboxypeptidase D

P03764 Side tail fiber protein

P14384 Carboxypeptidase M

P16397 Bacillopeptidase F

P42787 Carboxypeptidase D

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012103	Peptidase S8A, bacillopeptidase F
IPR015567	Peptidase M14B, caboxypeptidase D unit2
IPR005068	Phage tail fiber repeat 2
IPR008757	Peptidase M6, immune inhibitor A
IPR000209	Peptidase S8/S53, subtilisin/kexin/sedolisin
IPR010259	Proteinase inhibitor I9, subtilisin propeptide
IPR000834	Peptidase M14, carboxypeptidase A
IPR015500	Peptidase S8, subtilisin-related
IPR014766	Carboxypeptidase, regulatory domain
IPR011083	Phage tail collar
IPR008969	Carboxypeptidase-like, regulatory domain
IPR013609	Prophage tail fibre N-terminal
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Haucke V, Wenk MR, Chapman ER, Farsad K, De Camilli P. Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation. EMBO J. 19 6011-9 2000 [PubMed: 11080148] http://dx.doi.org/10.1093/emboj/19.22.6011

Additional Reading Open in usermanual
	Reverter D, Maskos K, Tan F, Skidgel RA, Bode W. Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. J. Mol. Biol. 338 2004 257-69 [PubMed: 15066430] http://dx.doi.org/10.1016/j.jmb.2004.02.058
	Aloy P, Companys V, Vendrell J, Aviles FX, Fricker LD, Coll M, Gomis-Ruth FX. The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidases. J. Biol. Chem. 276 2001 16177-84 [PubMed: 11278909] http://dx.doi.org/10.1074/jbc.M011457200
	Gomis-Ruth FX, Companys V, Qian Y, Fricker LD, Vendrell J, Aviles FX, Coll M. Crystal structure of avian carboxypeptidase D domain II: a prototype for the regulatory metallocarboxypeptidase subfamily. EMBO J. 18 1999 5817-26 [PubMed: 10545093] http://dx.doi.org/10.1093/emboj/18.21.5817

InterPro 24.0