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InterPro: IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

Protein matchesHelp
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UniProtKB
Matches:
56668 proteins
AccessionHelp
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IPR014729 Rossmann-like_a/b/a_fold
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Domain
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InterPro RelationshipsHelp
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Children IPR001962 Asparagine synthase
IPR002500 Phosphoadenosine phosphosulphate reductase
IPR003694 NAD+ synthase
IPR004820 Cytidylyltransferase
IPR006016 UspA
IPR011063 PP-loop
IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
IPR015803 Cysteinyl-tRNA synthetase, class Ia, N-terminal
IPR015945 Arginyl-tRNA synthetase, class Ic, core
Found in IPR000924 Glutamyl/glutaminyl-tRNA synthetase, class Ic
IPR001278 Arginyl-tRNA synthetase, class Ic
IPR001308 Electron transfer flavoprotein, alpha subunit
IPR001518 Argininosuccinate synthase
IPR001674 GMP synthase, C-terminal
IPR002301 Isoleucyl-tRNA synthetase, class Ia
IPR002302 Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial
IPR002303 Valyl-tRNA synthetase, class Ia
IPR002304 Methionyl-tRNA synthetase, class Ia
IPR002305 Aminoacyl-tRNA synthetase, class Ib
IPR002306 Tryptophanyl-tRNA synthetase, class Ib
IPR002307 Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial
IPR002308 Cysteinyl-tRNA synthetase, class Ia
IPR002606 Riboflavin kinase/FAD synthetase
IPR002650 Sulphate adenylyltransferase
IPR002761 Protein of unknown function DUF71, ATP-binding domain
IPR002904 Lysyl-tRNA synthetase, class I
IPR003721 Pantoate-beta-alanine ligase
IPR004479 Exoenzyme S synthesis protein B/queuosine synthesis
IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
IPR004506 tRNA-specific 2-thiouridylase
IPR004508 Thioredoxin-independent 5'-adenylylsulphate reductase
IPR004526 Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic
IPR004527 Glutamyl-tRNA synthetase, class Ic, bacterial/mitochondrial
IPR005232 Conserved hypothetical protein CHP00268
IPR005237 Conserved hypothetical protein CHP00289
IPR005248 Probable nicotinate-nucleotide adenylyltransferase
IPR006015 Universal stress protein A
IPR006050 DNA photolyase, N-terminal
IPR006426 Asparagine synthase, glutamine-hydrolyzing
IPR008148 DNA photolyase, class 2
IPR011784 Sulphate adenylyltransferase, small subunit
IPR012089 2-thiocytidine tRNA biosynthesis protein, TtcA
IPR012094 Lysidine-tRNA(Ile) synthetase
IPR012121 ATPase, PP-loop, MJ1599-related
IPR012122 ATPase, PP-loop, MJ1016-related
IPR012183 FAD synthetase, molybdopterin binding
IPR012255 Electron transfer flavoprotein, beta subunit
IPR014133 Cryptochrome, DASH
IPR014134 Cryptochrome, plant
IPR014445 Glutamine-dependent NAD(+) synthetase, GAT domain-containing
IPR015624 Tyrosyl-tRNA synthetase, class Ib, archaeal/eukaryotic cytosolic
IPR016429 Bifunctional transcriptional regulator NadR
IPR016485 Tyrosine tRNA ligase, archaeal/eukaryotic
IPR017535 Asparagine synthase family amidotransferase
IPR017539 Exosortase 1 system-associated amidotransferase 1
IPR017598 Putative sulfurtransferase DndC
IPR017812 Mycothiol biosynthesis protein, MshC
IPR018317 Queuosine synthesis-like
IPR018318 tRNA methyl transferase-like
IPR018353 Isoleucyl-tRNA synthetase
IPR019947 Deoxyribodipyrimidine photo-lyase, 8-HDF type
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain
IPR020653 Tryptophanyl-tRNA synthetase, class Ib, archaeal
IPR020754 Lysyl-tRNA synthetase, class Ic
IPR020756 Lysyl-tRNA synthetase, class I, archaeal-type
IPR020791 Leucyl-tRNA synthetase, class Ia, archaeal
IPR020792 Sulphate adenylyltransferase, subgroup
Contains IPR000049 Electron transfer flavoprotein, beta-subunit, conserved site
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR004821 Cytidyltransferase-related
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing
IPR014758 Methionyl-tRNA synthetase, class Ia, N-terminal
IPR015413 Aminoacyl-tRNA synthetase, class I (M)
IPR015864 FAD synthetase
IPR015905 Isoleucyl-tRNA synthetase, class Ia, N-terminal
IPR018223 Argininosuccinate synthase, conserved site
IPR019450 Nicotinamide mononucleotide adenylyltransferase, C-terminal
IPR019754 Valyl-tRNA synthetase, class Ia, N-terminal
IPR020060 Glutamyl/glutaminyl-tRNA synthetase, class Ic, N-terminal
IPR020554 Uncharacterised protein family UPF0021, conserved site
InterPro annotation
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AbstractHelp
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This entry represents domains related by a common ancestor that have a Rossmann-like, 3-layer, alpha/beta/alpha sandwich fold, as found in the protein families listed below:

  • Nucleotidylyl transferases (EC:2.7.7) such as cytidylyltransferases [1], adenylyltransferases [2].
  • Class I aminoacyl-tRNA synthetases (catalytic domain), such as tyrosyl-tRNA synthetase (EC:6.1.1.1) and glutaminyl-tRNA synthetase (EC:6.1.1.18) [3].
  • Pantothenate synthetases (EC:6.3.2.1) [4].
  • ATP sulphurylase (central domain) [5]
  • N-type ATP pyrophosphatases, such as beta-lactam synthetase (EC:6.3.3.4) and GMP synthase (EC:6.3.5.2) [6].
  • PP-loop ATPases such as the cell cycle protein MesJ (N-terminal domain) [7].
  • Phosphoadenylyl sulphate (PAPS) reductase [8]
  • Electron transfer flavoprotein (ETFP) subunits, such as the N-terminal domains of the alpha and beta subunits [9].
  • Universal stress protein A (UspA) [10].
  • Cryptochrome and DNA photolyase [11].
Structural linksHelp
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PDB - click here
1a8h , 1b6t , 1bs2 , 1coz , 1ct9 , 1d2r , 1dnp , 1ee1 , 1efp , 1efv , 1ej2 , 1f4l , 1f7u , 1f7v , 1ffy , 1fyd , 1g59 , 1g8f , 1g8g , 1g8h , 1gax , 1gln , 1gn8 , 1gpm , 1gzu , 1h1t , 1h3e , 1h3f , 1h3n , 1hyb , 1i2d , 1i6k , 1i6l , 1i6m , 1ifx , 1ih8 , 1iho , 1ile , 1iq0 , 1iqr , 1iqu , 1irx , 1ivs , 1iyw , 1j09 , 1j1u , 1j1z , 1j20 , 1j21 , 1j70 , 1jec , 1jed , 1jee , 1jgt , 1jhd , 1jii , 1jij , 1jik , 1jil , 1jmv , 1jzq , 1jzs , 1k4k , 1k4m , 1kam , 1kaq , 1kh1 , 1kh2 , 1kh3 , 1kku , 1kor , 1kqn , 1kqo , 1kqp , 1kr2 , 1li5 , 1li7 , 1lw7 , 1m1z , 1m83 , 1m8f , 1m8g , 1m8j , 1m8k , 1m8p , 1mau , 1maw , 1mb2 , 1mb9 , 1mbz , 1mc1 , 1mea , 1med , 1mjh , 1mop , 1n1d , 1n2b , 1n2e , 1n2g , 1n2h , 1n2i , 1n2j , 1n2o , 1n3l , 1n75 , 1n77 , 1n78 , 1ni5 , 1np7 , 1nsy , 1nup , 1nuq , 1nur , 1nus , 1nut , 1nuu , 1nzj , 1o5t , 1o6b , 1o94 , 1o95 , 1o96 , 1o97 , 1obc , 1obh , 1od6 , 1owl , 1owm , 1own , 1owo , 1owp , 1p7p , 1pfu , 1pfv , 1pfw , 1pfy , 1pg0 , 1pg2 , 1q11 , 1q15 , 1q19 , 1q77 , 1qjc , 1qnf , 1qqt , 1qu2 , 1qu3 , 1r6t , 1r6u , 1r6x , 1rqg , 1ru8 , 1sur , 1t9g , 1tez , 1tfu , 1tq8 , 1tya , 1tyb , 1tyc , 1tyd , 1u0b , 1u3c , 1u3d , 1u7d , 1u7x , 1udz , 1ue0 , 1ufv , 1ulh , 1v47 , 1v8f , 1vbm , 1vbn , 1vl2 , 1vlh , 1wjg , 1wk8 , 1wk9 , 1wka , 1wkb , 1wny , 1wnz , 1woy , 1wq3 , 1wq4 , 1wxe , 1wxf , 1wxg , 1wxh , 1wxi , 1wy5 , 1x6v , 1x8x , 1xjq , 1xng , 1xnh , 1xnj , 1y42 , 1yi8 , 1yia , 1yid , 1yul , 1yum , 1yun , 1zh0 , 1zh6 , 1zun , 2a1t , 2a1u , 2a4m , 2a7x , 2a84 , 2a86 , 2a88 , 2ag6 , 2ake , 2azx , 2b7l , 2csx , 2ct8 , 2cuz , 2cv0 , 2cv1 , 2cv2 , 2cya , 2cyb , 2cyc , 2d13 , 2d54 , 2d5b , 2der , 2det , 2deu , 2dlc , 2dpl , 2dr2 , 2dum , 2dxi , 2e21 , 2e89 , 2ejc , 2el7 , 2gm3 , 2hgz , 2hma , 2ip1 , 2j07 , 2j08 , 2j09 , 2nsy , 2nz2 , 2o5r , 2ov4 , 2pfs , 2pg3 , 2pid , 2pxh , 2pz8 , 2pza , 2pzb , 2quh , 2qui , 2quj , 2quk , 2ywb , 2ywc , 2yy5 , 2z08 , 2z09 , 2z3v , 2zlz , 3clr , 3cls , 3clt , 3clu , 3cov , 3cow , 3coy , 3coz , 3ts1 , 4ts1

Taxonomic coverageHelp
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Overlapping InterPro entriesHelp
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IPR014729 Numbers of overlapping proteins Average numbers of overlapping amino acids

Example proteinsHelp
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O43252 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1

O62431 Probable glutaminyl-tRNA synthetase

O77059 Cryptochrome-1

O88428 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2

P00958 Methionyl-tRNA synthetase, cytoplasmic

More proteins


Example Proteins Key


InterPro entry accession number/name and structure databases Colour code
IPR015947 Pseudouridine synthase/archaeosine transglycosylase-like
IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain
IPR002304 Methionyl-tRNA synthetase, class Ia
IPR014758 Methionyl-tRNA synthetase, class Ia, N-terminal
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR000924 Glutamyl/glutaminyl-tRNA synthetase, class Ic
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ic, catalytic domain
IPR002650 Sulphate adenylyltransferase
IPR004514 Glutaminyl-tRNA synthetase, class Ic
IPR006050 DNA photolyase, N-terminal
IPR002081 Cryptochrome/DNA photolyase, class 1
IPR007639 Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1
IPR020060 Glutamyl/glutaminyl-tRNA synthetase, class Ic, N-terminal
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
IPR002891 Adenylylsulphate kinase, C-terminal
IPR015413 Aminoacyl-tRNA synthetase, class I (M)
IPR018285 Methionyl-tRNA synthetase, N-terminal heteromerisation domain
IPR007638 Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2
IPR005101 DNA photolyase, FAD-binding/Cryptochrome, C-terminal
ModBase
SWISS-MODEL
PDB Chain
CATH Domain
SCOP Domain

PublicationsHelp
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1. Fong DH, Yim VC, D'Elia MA, Brown ED, Berghuis AM.
Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.
Biochim. Biophys. Acta 1764 63-9 2006 [PubMed: 16344011]
http://dx.doi.org/10.1016/j.bbapap.2005.10.015
2. Takahashi H, Inagaki E, Fujimoto Y, Kuroishi C, Nodake Y, Nakamura Y, Arisaka F, Yutani K, Kuramitsu S, Yokoyama S, Yamamoto M, Miyano M, Tahirov TH.
Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus.
Acta Crystallogr. D Biol. Crystallogr. 60 97-104 2004 [PubMed: 14684898]
3. Nureki O, Vassylyev DG, Katayanagi K, Shimizu T, Sekine S, Kigawa T, Miyazawa T, Yokoyama S, Morikawa K.
Architectures of class-defining and specific domains of glutamyl-tRNA synthetase.
Science 267 1958-65 1995 [PubMed: 7701318]
http://www.sciencemag.org/cgi/content/abstract/267/5206/1958
4. Wang S, Eisenberg D.
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action.
Biochemistry 45 1554-61 2006 [PubMed: 16460002]
http://dx.doi.org/10.1021/bi051873e
5. Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR.
Molecular basis for G protein control of the prokaryotic ATP sulfurylase.
Mol. Cell 21 109-22 2006 [PubMed: 16387658]
http://dx.doi.org/10.1016/j.molcel.2005.10.034
6. Tesmer JJ, Klem TJ, Deras ML, Davisson VJ, Smith JL.
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat. Struct. Biol. 3 74-86 1996 [PubMed: 8548458]
http://dx.doi.org/10.1038/nsb0196-74
7. Nakanishi K, Fukai S, Ikeuchi Y, Soma A, Sekine Y, Suzuki T, Nureki O.
Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain.
Proc. Natl. Acad. Sci. U.S.A. 102 7487-92 2005 [PubMed: 15894617]
http://dx.doi.org/10.1073/pnas.0501003102
8. Savage H, Montoya G, Svensson C, Schwenn JD, Sinning I.
Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases.
Structure 5 895-906 1997 [PubMed: 9261082]
http://dx.doi.org/10.1016/S0969-2126(97)00244-X
9. Roberts DL, Frerman FE, Kim JJ.
Three-dimensional structure of human electron transfer flavoprotein to 2.1-A resolution.
Proc. Natl. Acad. Sci. U.S.A. 93 14355-60 1996 [PubMed: 8962055]
http://dx.doi.org/10.1073/pnas.93.25.14355
10. Boes N, Schreiber K, Hartig E, Jaensch L, Schobert M.
The Pseudomonas aeruginosa universal stress protein PA4352 is essential for surviving anaerobic energy stress.
J. Bacteriol. 188 6529-38 2006 [PubMed: 16952944]
http://dx.doi.org/10.1128/JB.00308-06
11. Huang Y, Baxter R, Smith BS, Partch CL, Colbert CL, Deisenhofer J.
Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity.
Proc. Natl. Acad. Sci. U.S.A. 103 17701-6 2006 [PubMed: 17101984]
http://dx.doi.org/10.1073/pnas.0608554103

Additional ReadingHelp
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Karlberg T, Collins R, van den Berg S, Flores A, Hammarstrom M, Hogbom M, Holmberg Schiavone L, Uppenberg J.
Structure of human argininosuccinate synthetase.
Acta Crystallogr. D Biol. Crystallogr. 64 2008 279-86 [PubMed: 18323623]
http://dx.doi.org/10.1107/S0907444907067455
Malkowski MG, Quartley E, Friedman AE, Babulski J, Kon Y, Wolfley J, Said M, Luft JR, Phizicky EM, DeTitta GT, Grayhack EJ.
Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.
Proc. Natl. Acad. Sci. U.S.A. 104 2007 6678-83 [PubMed: 17426150]
http://dx.doi.org/10.1073/pnas.0610337104
Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C.
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem 9 2008 2606-11 [PubMed: 18821554]
http://dx.doi.org/10.1002/cbic.200800437
Shen N, Zhou M, Yang B, Yu Y, Dong X, Ding J.
Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states.
Nucleic Acids Res. 36 2008 1288-99 [PubMed: 18180246]
http://dx.doi.org/10.1093/nar/gkm1153
Blaise M, Olieric V, Sauter C, Lorber B, Roy B, Karmakar S, Banerjee R, Becker HD, Kern D.
Crystal structure of glutamyl-queuosine tRNAAsp synthetase complexed with L-glutamate: structural elements mediating tRNA-independent activation of glutamate and glutamylation of tRNAAsp anticodon.
J. Mol. Biol. 381 2008 1224-37 [PubMed: 18602926]
http://dx.doi.org/10.1016/j.jmb.2008.06.053
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