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InterPro: IPR014720 Double-stranded RNA-binding-like

Protein matches Help

UniProtKB

Matches:

4819 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR014720 dsRNA-bd-like

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.30.160.20	dsRNA-bd-like	4819
Signatures in BioMart

InterPro Relationships Help

Children

IPR001159 Double-stranded RNA binding
IPR013810 Ribosomal protein S5, N-terminal

Found in

IPR011907 Ribonuclease III, bacterial

Contains

IPR018192 Ribosomal protein S5, N-terminal, conserved site

GO Term annotation Help

Function

GO:0003723 RNA binding

Component

GO:0005622 intracellular

InterPro annotation

Entry Details in BioMart

Abstract

The double-stranded RNA-binding domain (dsRBD), which is found in a variety of proteins, shares a common structure with the N-terminal domain of ribosomal protein S5, namely an alpha-beta(3)-alpha structure that folds into two layers, alpha/beta [1]. The dsRBD is found in a variety of functionally distinct proteins, including Drosophila staufen proteins (five copies of motif), dsRNA-dependent protein kinase pkr, and RNase III. Ribosomal protein S5 functions in the small ribosomal subunit, and in Escherichia coli has been shown to be important in the assembly and function of the 30S subunit.

Structural links Help

PDB - click here

SCOP: d.50.1.1 , d.50.1.2 , i.1.1.1 , i.1.1.3

CATH: 3.30.160.20

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR014720

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O70133 ATP-dependent RNA helicase A

O75569 Interferon-inducible double stranded RNA-dependent protein kinase activator A

P25159 Maternal effect protein staufen

P34529 Endoribonuclease dcr-1

Q02555 Ribonuclease 3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005034	Dicer double-stranded RNA-binding fold
IPR006935	Restriction endonuclease, type I, R subunit/Type III, Res subunit
IPR003100	Argonaute/Dicer protein, PAZ
IPR001159	Double-stranded RNA binding
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR000999	Ribonuclease III
IPR011709	Domain of unknown function DUF1605
IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
IPR001650	DNA/RNA helicase, C-terminal
IPR007502	Helicase-associated domain
IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001	DEAD-like helicase, N-terminal
IPR014720	Double-stranded RNA-binding-like
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Bycroft M, Grunert S, Murzin AG, Proctor M, St Johnston D. NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5. EMBO J. 14 3563-71 1995 [PubMed: 7628456] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=7628456

Additional Reading Open in usermanual
	Laurberg M, Asahara H, Korostelev A, Zhu J, Trakhanov S, Noller HF. Structural basis for translation termination on the 70S ribosome. Nature 454 2008 852-7 [PubMed: 18596689] http://dx.doi.org/10.1038/nature07115
	Kurata S, Weixlbaumer A, Ohtsuki T, Shimazaki T, Wada T, Kirino Y, Takai K, Watanabe K, Ramakrishnan V, Suzuki T. Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J. Biol. Chem. 283 2008 18801-11 [PubMed: 18456657] http://dx.doi.org/10.1074/jbc.M800233200
	Borovinskaya MA, Shoji S, Fredrick K, Cate JH. Structural basis for hygromycin B inhibition of protein biosynthesis. RNA 14 2008 1590-9 [PubMed: 18567815] http://dx.doi.org/10.1261/rna.1076908
	Gan J, Shaw G, Tropea JE, Waugh DS, Court DL, Ji X. A stepwise model for double-stranded RNA processing by ribonuclease III. Mol. Microbiol. 67 2008 143-54 [PubMed: 18047582]
	Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolic S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N. A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing. Nature 452 2008 108-11 [PubMed: 18288106] http://dx.doi.org/10.1038/nature06683

InterPro 23.1