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InterPro: IPR014718 Glycoside hydrolase-type carbohydrate-binding, subgroup

Protein matches Help

UniProtKB

Matches:

4091 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR014718 Glyco_hydro-type_carb-bd_sub

Secondary

IPR004199

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:2.70.98.10	Glyco_hydro_42_D5	4091
Signatures in BioMart

InterPro Relationships Help

Parent

IPR011013 Glycoside hydrolase-type carbohydrate-binding

Children

IPR003159 Polysaccharide lyase family 8, central domain
IPR004199 Glycoside hydrolase, family 42, domain 5
IPR015220 Glucodextranase N

Found in

IPR006425 Glucan 1,4-alpha-glucosidase
IPR008183 Aldose 1-epimerase
IPR013458 Galactose mutarotase
IPR015443 Aldose-1-epimerase

Contains

IPR018052 Aldose 1-epimerase, conserved site

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0003824 catalytic activity
GO:0030246 carbohydrate binding

InterPro annotation

Entry Details in BioMart

Abstract

This domain has a distorted supersandwich structure consisting of 18 strands in two sheets, and probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase (EC:5.1.3.3); domain 5 of beta-galactosidase (EC:3.2.1.23); the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC (EC:4.2.2.5), chrondroitin ABC lyase I, and hyaluronate lyase (EC:4.2.2.1) itself [1]; and the N-terminal domain of bacterial glucoamylase (EC:3.2.1.3) [2].

Structural links Help

PDB - click here

SCOP: b.30.5.1 , b.30.5.2 , b.30.5.4 , b.30.5.5 , b.30.5.7

CATH: 1.50.10.100 , 2.60.220.10 , 2.70.98.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR014718

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P00722 Beta-galactosidase

P04397 Bifunctional protein GAL10

Q5EA79 Aldose 1-epimerase

Q8K157 Aldose 1-epimerase

Q96C23 Aldose 1-epimerase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014718	Glycoside hydrolase-type carbohydrate-binding, subgroup
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR004199	Glycoside hydrolase, family 42, domain 5
IPR013812	Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
IPR018052	Aldose 1-epimerase, conserved site
IPR011013	Glycoside hydrolase-type carbohydrate-binding
IPR016040	NAD(P)-binding domain
IPR006101	Glycoside hydrolase, family 2
IPR001509	NAD-dependent epimerase/dehydratase
IPR008979	Galactose-binding domain-like
IPR015443	Aldose-1-epimerase
IPR006104	Glycoside hydrolase family 2, carbohydrate-binding
IPR017853	Glycoside hydrolase, catalytic core
IPR006102	Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich
IPR008183	Aldose 1-epimerase
IPR006103	Glycoside hydrolase family 2, TIM barrel
IPR005886	UDP-glucose 4-epimerase
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Volpi N, Maccari F. Purification and characterization of hyaluronic acid from the mollusc bivalve Mytilus galloprovincialis. Biochimie 85 619-25 2003 [PubMed: 12829379] http://dx.doi.org/10.1016/S0300-9084(03)00083-X
2.	Ducki A, Grundmann O, Konermann L, Mayer F, Hoppert M. Glucoamylase from Thermoanaerobacterium thermosaccharolyticum: Sequence studies and analysis of the macromolecular architecture of the enzyme. J. Gen. Appl. Microbiol. 44 327-335 1998 [PubMed: 12501412]

Additional Reading Open in usermanual
	Maruyama Y, Mikami B, Hashimoto W, Murata K. A structural factor responsible for substrate recognition by Bacillus sp. GL1 xanthan lyase that acts specifically on pyruvated side chains of xanthan. Biochemistry 46 2007 781-91 [PubMed: 17223699] http://dx.doi.org/10.1021/bi0619775
	Thoden JB, Holden HM. The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae. J. Biol. Chem. 280 2005 21900-7 [PubMed: 15795221] http://dx.doi.org/10.1074/jbc.M502411200
	Rigden DJ, Littlejohn JE, Joshi HV, de Groot BL, Jedrzejas MJ. Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: insights into enzyme flexibility and underlying molecular mechanism of action. J. Mol. Biol. 358 2006 1165-78 [PubMed: 16569416] http://dx.doi.org/10.1016/j.jmb.2006.02.066
	Rigden DJ, Botzki A, Nukui M, Mewbourne RB, Lamani E, Braun S, von Angerer E, Bernhardt G, Dove S, Buschauer A, Jedrzejas MJ. Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. Glycobiology 16 2006 757-65 [PubMed: 16638841] http://dx.doi.org/10.1093/glycob/cwj116
	Maruyama Y, Hashimoto W, Mikami B, Murata K. Crystal structure of Bacillus sp. GL1 xanthan lyase complexed with a substrate: insights into the enzyme reaction mechanism. J. Mol. Biol. 350 2005 974-86 [PubMed: 15979090] http://dx.doi.org/10.1016/j.jmb.2005.05.055

InterPro 23.1