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InterPro: IPR014397 L-aminoadipate-semialdehyde dehydrogenase, large subunit

Protein matches Help

UniProtKB

Matches:

70 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR014397 L-NH2adipate-semiAld_DH_lsu

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF001617	Alpha-AR	43
TIGRFAMs	TIGR03443	alpha_am_amid	70
Signatures in BioMart

InterPro Relationships Help

Contains

IPR006163 Phosphopantetheine-binding
IPR009081 Acyl carrier protein-like
IPR010071 Amino acid adenylation
IPR010080 Thioester reductase
IPR020845 AMP-binding, conserved site

GO Term annotation Help

Process

GO:0009085 lysine biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity
GO:0031177 phosphopantetheine binding

InterPro annotation

Entry Details in BioMart

Abstract

This group represents the large subunit of L-aminoadipate-semialdehyde dehydrogenase. This enzyme catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH [1].

Database links Help

Enzyme: EC:1.2.1.31

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR014397

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O74298 L-aminoadipate-semialdehyde dehydrogenase large subunit

P07702 L-aminoadipate-semialdehyde dehydrogenase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016040	NAD(P)-binding domain
IPR010080	Thioester reductase
IPR014397	L-aminoadipate-semialdehyde dehydrogenase, large subunit
IPR013120	Male sterility, NAD-binding
IPR006162	Phosphopantetheine attachment site
IPR009081	Acyl carrier protein-like
IPR006163	Phosphopantetheine-binding
IPR020845	AMP-binding, conserved site
IPR010071	Amino acid adenylation
IPR000873	AMP-dependent synthetase/ligase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Casqueiro J, Gutierrez S, Banuelos O, Fierro F, Velasco J, Martin JF. Characterization of the lys2 gene of Penicillium chrysogenum encoding alpha-aminoadipic acid reductase. Mol. Gen. Genet. 259 549-56 1998 [PubMed: 9790587] http://dx.doi.org/10.1007/s004380050847

InterPro 23.1