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InterPro: IPR013954 Polynucleotide kinase 3 phosphatase, central region

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559 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR013954 PNK3P_central-region

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08645	PNK3P	559
Signatures in BioMart

InterPro Relationships Help

Children

IPR006551 DNA 3-phosphatase

Found in

IPR005954 Histidinol-phosphatase
IPR006543 Histidinol-phosphate phosphatase
IPR006549 HAD-superfamily hydrolase, subfamily IIIA
IPR020566 Histidine biosynthesis bifunctional protein hisB

InterPro annotation

Entry Details in BioMart

Abstract

Polynucleotide kinase 3 phosphatases play a role in the repair of single breaks in DNA induced by DNA-damaging agents such as gamma radiation and camptothecin [1].

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PDB - click here

SCOP: c.108.1.19 , c.108.1.9

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Enzyme: EC:3.1.3

Pfam Clan: CL0137.11

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013954

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q03796 Polynucleotide 3'-phosphatase

Q19683 Uncharacterized protein F21D5.5

Q96T60 Bifunctional polynucleotide phosphatase/kinase

Q9JLV6 Bifunctional polynucleotide phosphatase/kinase

Q9S5G5 Histidine biosynthesis bifunctional protein hisB

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR000807	Imidazoleglycerol-phosphate dehydratase
IPR006551	DNA 3-phosphatase
IPR006550	Polynucleotide kinase 3-phosphatase
IPR020565	Imidazoleglycerol-phosphate dehydratase, conserved site
IPR020566	Histidine biosynthesis bifunctional protein hisB
IPR006549	HAD-superfamily hydrolase, subfamily IIIA
IPR006543	Histidinol-phosphate phosphatase
IPR005954	Histidinol-phosphatase
IPR013954	Polynucleotide kinase 3 phosphatase, central region
IPR015636	Polynucleotide kinase 3, phosphatase
IPR008984	SMAD/FHA domain
	PDB Chain
	ModBase
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Meijer M, Karimi-Busheri F, Huang TY, Weinfeld M, Young D. Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. J. Biol. Chem. 277 4050-5 2002 [PubMed: 11729194] http://dx.doi.org/10.1074/jbc.M109383200

Additional Reading Open in usermanual
	Jilani A, Ramotar D. Purification and partial characterization of a DNA 3'-phosphatase from Schizosaccharomyces pombe. Biochemistry 41 2002 7688-94 [PubMed: 12056900] http://dx.doi.org/10.1021/bi012213m
	Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M. Molecular characterization of a human DNA kinase. J. Biol. Chem. 274 1999 24187-94 [PubMed: 10446193] http://dx.doi.org/10.1074/jbc.274.34.24187
	Vance JR, Wilson TE. Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1). J. Biol. Chem. 276 2001 15073-81 [PubMed: 11278831] http://dx.doi.org/10.1074/jbc.M011075200
	Rangarajan ES, Proteau A, Wagner J, Hung MN, Matte A, Cygler M. Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway. J. Biol. Chem. 281 2006 37930-41 [PubMed: 16966333] http://dx.doi.org/10.1074/jbc.M604916200
	Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN. The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Mol. Cell 17 2005 657-70 [PubMed: 15749016] http://dx.doi.org/10.1016/j.molcel.2005.02.012

InterPro 23.1